CHLA Clinical Research Studies

Having volunteers participate in research studies and clinical trials is critical to our research efforts. Thousands of children and families are involved in our patient-centered studies every year. Many of the treatments used today are based on the results of past research studies and clinical trials conducted with our patients. Our scientific and clinical experts take the best ideas from the laboratory -- to the patient -- in the form of promising new treatments.

By searching our study directory, you may identify research that could impact the life of your child or of another child you know. Because the number of available research studies and clinical trials for children nationwide is small, every participant makes a significant contribution.

In addition to enrolling children with certain diseases in order to study treatments and prevention of those diseases, we also need to study healthy children. Ask your child’s doctor about volunteer study options that may be suitable for your child.

Please contact the study staff listed in your search results for more information.

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Study Details - ID: CHLA-17-00496
Health/Science/Disease Category:
Chronic Anemia Syndromes (sickle cell disease and thalassemia)
Purpose of Research:
A study to look at how having chronic anemia impacts the brain
Short Name:
Cerebrovascular Reserve Study
Full Title of Study:
Cerebrovascular Reserve and White Matter Disease in Patients with Chronic Anemia
Phase/Type of Study:
1) Sickle cell disease or Thalassemia with 7 years and above 2) Healthy volunteers who are Hispanic or African American and 18 years and above 3) Able to tolerate 1 hour of MRI 4) Not pregnant or nursing
Time Commitment/Requirements:
1 day visit of about 3-4 hours. Compensation provided.
Primary Investigator:
John Wood, MD
Coordinator Contact Name:
Mike K. Gawad, BSc, CCRP or Obdulio Carreras
Phone Number:
(323) 361-3313 or 323-361-4100
Email: or
Clinical Trials .Gov Identifier: