CHLA Clinical Research Studies

Having volunteers participate in research studies and clinical trials is critical to our research efforts. Thousands of children and families are involved in our patient-centered studies every year. Many of the treatments used today are based on the results of past research studies and clinical trials conducted with our patients. Our scientific and clinical experts take the best ideas from the laboratory -- to the patient -- in the form of promising new treatments.

By searching our study directory, you may identify research that could impact the life of your child or of another child you know. Because the number of available research studies and clinical trials for children nationwide is small, every participant makes a significant contribution.

In addition to enrolling children with certain diseases in order to study treatments and prevention of those diseases, we also need to study healthy children. Ask your child’s doctor about volunteer study options that may be suitable for your child.

Please contact the study staff listed in your search results for more information.

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Study Details - ID: CHLA-14-00451
Health/Science/Disease Category:
Extubation failure in newborn infants
Purpose of Research:
Validate the use of respiratory inductance plethysmography (RIP) and esophageal manometry in diagnosing upper airway obstruction (UAO) in newborn infants.
Short Name:
Extubation failure in newborn infants
Full Title of Study:
A study of incidence of upper airway obstruction and other risk factors of extubation failure in newborn infants
Phase/Type of Study:
This single center interventional study
Intubated and mechanically ventilated infants admitted to Newborn and Infant Critical Care Unit (NICCU) at the Children’s Hospital Los Angeles. Infants needed to have been intubated for at least 12 hours, with a plan for extubation by the clinical care team. Inclusion criteria also includes recent (within 24 hours) evidence of stable chest x-ray in advance of extubation and, where applicable, documentation of either closed or non-significant PDA on the last echocardiogram.
Time Commitment/Requirements:
Active participation will last a few hours. After that, the research team will continue to collect information about the patient's condition and treatment until discharge.
Primary Investigator:
Narayan Prabhu Iyer
Coordinator Contact Name:
Kinnedy Houston or Sharon Tang
Phone Number:
323-361-5088 or 323-361-7299
Email: or
Clinical Trials .Gov Identifier: