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DISCOVERIES AND INNOVATION

Our #WomenInScience Rock!

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They wear lab coats in place of capes, safety goggles instead of masks, and wield pipets - not swords. But they are still our heroes.

Feb 11th was International Day of Women and Girls in Science, and March 8th is International Women's Day. Did you know that more than half of funded investigators at CHLA are women? Please take a moment to celebrate some of the talented women who are saving lives from the laboratory! Visit ...

At the Heart of Research

Scientists at Children’s Hospital Los Angeles discover a mechanism that zebrafish use to regenerate damaged heart tissue. This research could lead to better treatments for babies in need of heart repair.

Cardiac lymphatic vessels (seen here in red) in the zebrafish heart help the fish repair damaged tissue after injury.

One of the reasons coronary heart disease is so deadly is that fluid build-up and scarring can...

A Higher Resolution Image of Human Lung Development

The invention of interactive map applications has revolutionized wayfinding, providing an unprecedented level of information far beyond what printed road maps can offer. Researchers at Children’s Hospital Los Angeles are giving us a similar look into the anatomy of the human lung, and their findings could help babies breathe easier.

Infants born prematurely often suffer from poor lung development and can face...

RESEARCH COMMUNITY

Health Complexities in Pediatrics: The Saban Research Institute’s Annual Symposium

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The Saban Research Institute’s Annual Symposium will take place on February 19, 2020. This year’s theme is Health Complexities in Pediatrics: Investigating Systems in Action and Interaction

The Saban Research Institute Annual Symposium highlights...

Peter Chiarelli, MD, PhD Wins Prestigious Award for Nanoparticle Research

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When it comes to pediatric brain cancers, research and treatments have made great strides. But some cancers do not respond to conventional treatments or grow deep within delicate areas of the brain, where surgical removal can be impossible.

Peter Chiarelli, MD, PhD, has received an award to...

Precision Medicine for Pediatric Cancer

Research performed over the last several decades has led to an increased understanding of the genetics of cancer. The clinical application of this knowledge for pediatric cancer has lagged behind studies performed for adults. In a perspectives article published in the prestigious journal Science, Dr. Jaclyn Biegel, from Children’s Hospital Los Angeles, and Dr. Alejandro...

NEWS

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Intestine grown from stem cells in Dr. Grikscheit’s laboratory. Children’s Hospital Los Angeles surgeon achieves milestone in using tissue engineering to grow complete gut nervous system. ​​ Babies with Hirschsprung’s disease are born with an...
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Children’s Hospital Los Angeles surgeon achieves milestone in preclinical research for Hirschsprung’s Disease  By Melinda Smith The human body has what is sometimes called a “second brain” in the digestive tract. The enteric nervous system (ENS) performs many vital...
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Elizabeth Sowell, PhD Adolescence is a time of great change, both emotionally, socially and physically. To understand how these changes affect the health of our nation’s children as they develop, the National Institutes of Health (NIH) has funded the...

Research videos

  • Leaders in Pediatric Health Through Scientific Discovery

    Children’s Hospital Los Angeles is ranked 5th nationally in US News and World Report’s list of top children’s hospitals. This recognized excellence in patient care would be impossible without the intimate relationship shared with our research enterprise. Watch as Chief Scientific Officer, Pat Levitt, PhD, introduces our research themes and discusses CHLA’s position as a leader in pediatric health through our scientific discoveries.

  • Family Philanthropy Benefits Research on Nephrology

    A documentary film about the GOFARR Fund for Children’s Hospital Los Angeles was recently screened at the Sun Valley Film Festival for Future Filmmakers. The film, “Believe: The Story of the GOFARR Fund,” was made by Amanda Schenkman and tells the story about her twin brother Gabriel and his journey with a congenital kidney condition.

    The Schenkman Family Fund supports nephrology research at CHLA overseen by Roger De Filippo, MD, FACS, FAAP and Laura Perin, PhD. At the GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, De Filippo and Perin focus on the development of new stem cell therapeutics and other techniques for organ regeneration.

  • Using Gene-Editing to Cure Type 1 Diabetes

    Senta Georgia, PhD, is creating new insulin-producing cells using CRISPR gene-editing technology in her work to cure genetic forms of diabetes.

  • Can Virtual Reality Help Manage Pain?

    Researchers at CHLA are studying the use of virtual reality to reduce pain in children and adolescents undergoing painful medical procedures. Jeffrey Gold, PhD, a clinical psychologist and director of the Pediatric Pain Management Clinic, explains his research.

  • Using Virtual Reality to Train Physicians for Pediatric Emergencies

    CHLA is using virtual reality to build skills and confidence to prepare medical students for real-life emergencies. Joshua Sherman, MD, an emergency medicine physician at CHLA, explains how.

  • Protecting the Brains of Infants with Therapeutic Cooling

    Investigators at Children's Hospital Los Angeles are using therapeutic cooling to protect the brains of newborns deprived of oxygen during birth. Jessica Wisnowski, PhD, and Tai-Wei Wu, MD, explain the process and why it works.