Research News Listing

Published on October 17, 2016
cropped.jpg Researchers at The Saban Research Institute of Children’s Hospital Los Angeles have identified an unsuspected and critical role of the MDM2 oncogene in promoting expression of the MYCN oncogene that is required for growth and survival of retinoblastoma cells.  Their results... Read More
Published on October 12, 2016
151712781032_0.jpg Recently, Yoshinori Ohsumi was awarded the 2016 Nobel Prize in Physiology or Medicine for his discoveries of mechanisms for a fundamental process called autophagy. Mutations in autophagy genes can cause disease, and disturbances in the autophagic process can lead to diabetes,... Read More
Published on October 11, 2016
Robert Seeger, MD, sized.jpg A study by a multidisciplinary team of researchers from The Saban Research Institute of Children’s Hospital Los Angeles sheds further light on the role of the cytokine TGFβ1 in the growth of neuroblastoma, and suggests the possibility for a small molecule drug/antibody... Read More
Published on September 30, 2016
151164595327_0.jpg The Food and Drug Administration has approved the first drug to treat patients with Duchenne muscular dystrophy, the most common muscular dystrophy diagnosed in childhood. Some experts contend that not enough evidence exists to prove the drug – eteplirsen – is effective, because... Read More
Published on September 28, 2016
151066738222_0.jpg Join Rita Burke, PhD, MPH. on a Twitter chat about disaster preparedness for families | September 29 between 1 – 2 PM EST at www.PHE.gov/Prep2Grow | Sponsored by the U. S. Office of the Assistant Secretary of Preparedness and Response Hurricane Katrina was a wakeup call to... Read More
Published on September 23, 2016
150827093077_0.jpg Military personnel can be exposed to dusts and toxicants in the field that may contribute to lung disease. The available technologies to detect early-stage alterations of lung function in patients require a long processing time and lack satisfactory sensitivity and resolution,... Read More
Published on September 16, 2016
150511135322_0.jpg Recent studies have indicated an increased need for preventive mental health and social services among Filipinos, in part because of higher rates of problem behaviors such as substance use, high school dropout, and teen births compared to other Asian subgroups. Filipino... Read More
Published on September 14, 2016
David Warburton resized.jpg Real-time endoscopic monitoring technology expected to improve respiratory health of military personnel in the field David Warburton, MD, of The Saban Research Institute of Children’s Hospital Los Angeles (CHLA) has been awarded more than $2.3 million from the Department of... Read More
Published on September 14, 2016
150405989342_0.jpg In a first-of-its-kind look at human kidney development, researchers at The Saban Research Institute of Children’s Hospital Los Angeles have isolated human nephron progenitor (NP) cells.  Their results, published online in the journal Stem Cell Translational Medicine, will help... Read More
Published on September 12, 2016
Perrin resized.jpg In a first-of-its-kind look at human kidney development, researchers at The Saban Research Institute of Children’s Hospital Los Angeles have isolated human nephron progenitor (NP) cells.  Their results, published online in the journal Stem Cell Translational Medicine, will... Read More
Published on September 9, 2016
150176772772_0.jpg Surface of the mouse colon repaired by stem cells after a flare of ulcerative colitis. The different colors show the contributions of individual stem cells as they have multiplied to patch the breaks, or ulcers, in the colonic surface. These ulcers were originally caused by the... Read More
Published on September 6, 2016
150036059912_0.jpg Genetic Intersection of Conditions AnalyzedResearchers at the Institute for the Developing Mind at Children’s Hospital Los Angeles have analyzed current gene-disease findings to understand why people with neurodevelopmental and mental illness often have physical disorders.Their... Read More
Published on September 2, 2016
149846697252_0.jpg Concussions are a form of mild traumatic brain injury resulting in transient functional and biochemical changes in the brain. According to a study conducted by researchers at the University of California, San Francisco, the rates of concussions are purportedly on the rise among... Read More
Published on September 1, 2016
21386-chla-placeholders_320x165_v2_0.jpg Co-occurrences could have broad clinical implications for patient care over a lifetime Researchers at the Institute for the Developing Mind at Children’s Hospital Los Angeles have analyzed current gene-disease findings to understand why people with neurodevelopmental and... Read More
Published on August 30, 2016
149717918742_0.jpg biodegradable scaffold (left) and human tissue-engineered liver (right)A research team led by investigators at The Saban Research Institute of Children’s Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells.... Read More
Published on August 30, 2016
human Teli-1  web.jpg A research team led by investigators at The Saban Research Institute of Children’s Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells. Tissue-engineered Liver (TELi) was found to contain normal structural... Read More
Published on August 26, 2016
149515633142_0.jpg Delirium is an acute neurologic dysfunction, defined by the DSM IV as an acute change in consciousness with impairments in attention and cognition. Over the decades critical care literature has referred to the condition with a variety of terms, most commonly ICU psychosis.... Read More
Published on August 23, 2016
149375097732_0.jpg An article aimed at kids 10 to 15-years old by researchers Elizabeth R. Sowell, PhD, Kristina Uban and Megan Herting from Children’s Hospital Los Angeles asks the provocative question: Imagine that your family was given a million dollars.  How would your life change? The article... Read More
Published on August 19, 2016
149187714967_0.jpg In an innovative, first-in-pediatrics study, available only at Children’s Hospital Los Angeles (CHLA), researchers will be enrolling children between 1 and 18 years of age who have certain types of relapsed or treatment-resistant cancer.The aim of this investigator-initiated... Read More
Published on August 17, 2016
Leo Mascarenhas, MD.jpg In an innovative, first-in-pediatrics study, available only at Children’s Hospital Los Angeles (CHLA), researchers will be enrolling children between 1 and 18 years of age who have certain types of relapsed or treatment-resistant cancer. The aim of this investigator-initiated... Read More

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