Research News Listing

Published on April 14, 2016
Retinoblastoma tumor cells, web.jpg Use of Chemotherapy with a Survivin Inhibitor Improves Treatment Responses in Retinoblastoma Cells and Ocular Tumor Models Researchers at The Saban Research Institute of Children’s Hospital Los Angeles (CHLA) have demonstrated that targeting survivin – a protein that inhibits... Read More
Published on April 11, 2016
Stem cell-derived retina, web.jpg Study seeks to improve understanding of light-sensitive cells in the retina that initiate daylight vision David E. Cobrinik, MD, PhD, of The Vision Center at Children’s Hospital Los Angeles (CHLA) has been awarded a four-year grant totaling $1.665 million from the National... Read More
Published on April 5, 2016
Frey_sheddingCells, web.jpg The lining of the intestine is the most rapidly-renewing tissue in the body. Routine shedding of epithelial cells from this lining is a key element of tissue turnover, and is thus essential to maintaining optimal health. Altered shedding is associated with multiple disorders,... Read More
Published on March 29, 2016
21386-chla-placeholders_320x165_v2_0.jpg Phase 1/Phase 2 study offers major new approach to treating cancer The Children’s Center for Cancer and Blood Diseases (CCCBD) at Children’s Hospital Los Angeles is one of the first sites in the world to offer a promising new investigational therapy to treat pediatric acute... Read More
Published on March 24, 2016
MontageCellReportCHLA_PR-T 50% web.jpg A new study led by researchers at The Saban Research Institute of Children’s Hospital Los Angeles (CHLA) reports that the presence of leptin – a hormone secreted by fat cells that is critical to maintaining energy balance in the body -- inhibits the prenatal development of... Read More
Published on March 22, 2016
Untitled2.jpg Douglas Nordli, Jr., MD, has been named chief of the Division of Pediatric Neurology and co-director of the Neurosciences Institute at Children’s Hospital Los Angeles (CHLA). Dr. Nordli, who will also serve as a vice chair of Neurology at the Keck School of Medicine of the... Read More
Published on March 17, 2016
Tracy C. Grikscheit, MD, web.jpg Grant will fund development of cellular therapy to treat digestive nerve disorders Tracy C. Grikscheit, MD, of The Saban Research Institute of Children’s Hospital Los Angeles has received a $7.1 million grant from the California Institute of Regenerative Medicine... Read More
Published on March 14, 2016
CT images 2 - nc, web.jpg Children with a severe type of spina bifida called myelomeningocele have a high prevalence of obesity and excess fat accumulation in their lower extremities.  In a study designed to assess bone, muscle and fat tissue distribution in the lower legs of children with this... Read More
Published on March 10, 2016
cropped, web.jpg Study suggests macrophage activation as possible reason for differential bone loss in adolescent males Accumulating evidence suggests that rates of low bone mass are greater in HIV-infected males than in females. Researchers led by Grace Aldrovandi, MD, chief of the Division... Read More
Published on February 23, 2016
Robert Seeger, MD, sized.jpg Robert Seeger, MD, division head for Basic and Translational Research of the Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles (CHLA) has been selected for the 2016 Lifetime Achievement Award from the Pediatric Blood and Marrow Transplant Consortium (PBMC... Read More
Published on February 18, 2016
shutterstock_232207735 (1).jpg Children’s Hospital Los Angeles (CHLA) and Thermo Fisher Scientific have agreed to develop a next-generation sequencing (NGS)-based panel designed specifically for pediatric cancer research.  The assay would be CHLA’s first NGS panel designed to target biomarkers associated... Read More
Published on February 10, 2016
GrikWieck PLOS web.jpg Investigators at The Saban Research Institute of Children’s Hospital Los Angeles have created a novel model for studying a lung disorder of newborn babies. Their study, published in PLOS ONE on February 10, describes the first model that allows investigators to consider the... Read More
Published on February 4, 2016
Etan Orgel, MD, MS.jpg Investigators at Children’s Hospital Los Angeles have found that significant bone loss – a side effect of chemotherapy for acute lymphoblastic leukemia (ALL) – occurs during the first month of treatment, far earlier than previously assumed. Results of the study will be available... Read More
Published on January 28, 2016
resize.jpg An interdisciplinary research team at The Saban Research Institute of Children’s Hospital Los Angeles has found that body mass index (BMI) is an inadequate method for estimating changes in body fat and obesity in children with leukemia. Investigators determined that the... Read More
Published on January 27, 2016
MarachellianNewsroom.png Building upon more than two decades of basic research conducted at Children’s Hospital Los Angeles, Araz Marachelian, MD, of CHLA, and her colleagues at pediatric academic centers across the U. S., have shown that an immunotherapy that until now has only been available to... Read More
Published on January 20, 2016
Depression cover image.jpg Building on a 30-year, three-generation study of depressed individuals, their children and offspring, a study published in the journal Psychiatry Research: Neuroimaging provides a better understanding of the familial risk for depression and the role neuroplasticity might have in... Read More
Published on December 16, 2015
21386-chla-placeholders_320x165_v2_0.jpg Two philanthropic gifts, totaling $4 million, have been pledged in support of The Vision Center at Children’s Hospital Los Angeles, an international referral center for children with complex eye diseases. A $2 million gift from the Larry & Celia Moh Foundation to The... Read More
Published on December 3, 2015
Newborn brain images V2.jpg In the first study of its kind, researchers have shown that inadequate maternal iron intake during pregnancy exerts subtle effects on infant brain development.  Their findings have been published online by the journal Pediatric Research. The research—led by principal... Read More
Published on November 30, 2015
facial expressions.jpg Individuals with autism spectrum disorder (ASD) often have difficulty recognizing and interpreting how facial expressions convey various emotions – from joy to puzzlement, sadness to anger.  This can make it difficult for an individual with ASD to successfully navigate... Read More
Published on November 3, 2015
ORGEL, ETAN 2.jpg More children are surviving malignant brain tumors than in the past, thanks to the use of intense treatments using platinum-based chemotherapy (cisplatin and high-dose carboplatin).  Unfortunately, the therapy has a known side effect of permanent hearing loss,... Read More

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