Research News Listing

Published on February 27, 2018
CHLA-Bradley-Peterson.jpg Stress and other factors can trigger immune response A landmark study published in the Journal of Neuroscience on February 26 reveals that activation of a pregnant mother’s immune system can affect her baby’s brain development. A team of researchers led by Bradley Peterson,... Read More
Published on February 21, 2018
LM.jpg Children’s Hospital Los Angeles one of 25 sites in international study of larotrectinib Three quarters of patients, both adults and children, with a variety of advanced cancers occurring in different sites of the body responded to larotrectinib, a novel therapy that targets a... Read More
Published on February 5, 2018
Jasmine_HLHS Consortium web.jpg Children's Hospital Los Angeles is announcing participation in the first-ever clinical trial using stem cells from umbilical cord blood to delay or even prevent heart failure in children born with a rare congenital heart defect that leaves them with half a heart. The Phase I... Read More
Published on February 1, 2018
Michael  Pulsipher, MD, CHLA3.jpg Detailed analysis of patient data now available Results of the global, multicenter, pivotal phase 2 study that led to the first FDA approval of a gene therapy/cell therapy approach known as CAR T-cell therapy, were published on January 31 in the New England Journal of... Read More
Published on December 14, 2017
Laura Perin, PhD_0 (1) 2017 web.jpg Study findings indicate a more effective way to slow organ damage in Alport syndrome Researchers have demonstrated for the first time that extracellular vesicles – tiny protein-filled structures – isolated from amniotic fluid stem cells (AFSCs) can be used to effectively... Read More
Published on November 28, 2017
167991044637_0.jpg David Warburton, MD, has been elected a 2017 Fellow of the American Association for the Advancement of Science (AAAS) in recognition his contributions to innovation, education, and scientific leadership in the Section of Medical Sciences.  Warburton, who is the director of the... Read More
Published on November 20, 2017
CHLA-D.Brent Polk, MD.jpg Findings may point to new treatment approaches for patients with IBD D. Brent Polk, MD, AGAF, an investigator at Children’s Hospital Los Angeles, has been awarded $1.5 million by the National Institute of Diabetes and Digestive and Kidney Diseases of the NIH for the study of... Read More
Published on November 14, 2017
167493169922_0.jpg A protein lining the inner layer of the heart. The protein is required for heart muscles to proliferate during development.Ram Kumar Subramanyan, MD, PhD, brings a unique point of view to the laboratory, where his goal is to one day use stem cells to create replacement parts for... Read More
Published on November 13, 2017
CHLA-St. Baldrick's Foundation check presentation at CHLA.jpg Three physician-researchers with the Children’s Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles (CHLA) have been awarded more than $1 million in grants from the St. Baldrick’s Foundation, the largest private funder of childhood cancer research. The... Read More
Published on November 7, 2017
167249347602_0.jpg The Sharon D. Lund Foundation has awarded $400,000 to Michele Kipke, PhD, vice chair of Research and division head of Research on Children, Youth and Families. The funding will support research efforts of the Boone Fetter Clinic and the Institute for the Developing Mind to... Read More
Published on November 7, 2017
CHLA-Jeffrey-Gold.jpg Study finds that virtual reality is effective in reducing pain during certain medical procedures Virtual reality has emerged into popular culture with an ever-widening array of applications including clinical use in a pediatric healthcare center. Children undergo necessary... Read More
Published on November 6, 2017
CHLA-Pulsipher2.jpg New Cellular Therapy Approach for Children with Compromised Immune Systems Michael Pulsipher, MD, of the Children’s Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles, along with Michael Keller, MD from Children’s National Health System in Washington, DC... Read More
Published on October 31, 2017
CHLA-Sheree Schrager, PhD.jpg   Findings expected to enable development of targeted and effective interventions for LGB youth at risk Sheree Schrager, PhD, MS, an investigator at Children's Hospital Los Angeles, and fellow investigator, Jeremy Goldbach, PhD, of the USC Suzanne Dworak-Peck... Read More
Published on October 18, 2017
MRI of newborn infant brain and 3-D image of subcortical structures.web_.jpg Findings expected to enable design of early interventions to improve healthy neurodevelopment Natasha Leporé, PhD, a principal investigator in the Department of Radiology and Imaging at Children’s Hospital Los Angeles, has been awarded $1.7 million from the National Institute... Read More
Published on October 12, 2017
Surgeons web.jpg Study indicates proof of concept for using a surrogate liquid biopsy to provide genetic profile of retinoblastoma tumors Retinoblastoma is a tumor of the retina that generally affects children under 5 years of age. If not diagnosed early, retinoblastoma may result in loss of... Read More
Published on October 10, 2017
166269785577_0.jpg Investigators identify pathway that causes immune cells to support cancer, instead of killing itInvestigators at the Children’s Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles have identified new findings about an immune cell – called a tumor-... Read More
Published on October 6, 2017
166126027907_0.jpg New Biomarker Assay Detects Neuroblastoma with Greater Sensitivity Investigators at The Saban Research Institute of Children’s Hospital Los Angeles have developed and tested a new biomarker assay for quantifying disease and detecting the presence of neuroblastoma even when... Read More
Published on October 5, 2017
CHLA-Pulsipher2.jpg Children’s Hospital Los Angeles receives $9 million from NIH to study “bubble boy” syndrome Michael Pulsipher, MD, of the Children’s Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles, along with co-principal investigator, Sung-Yun Pai, MD, of Boston... Read More
Published on September 21, 2017
CHLA-Shahab-Asgharzadeh.jpg Investigators identify pathway that causes immune cells to support cancer, instead of killing it Investigators at the Children’s Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles have identified new findings about an immune cell – called a tumor-... Read More
Published on September 19, 2017
166588399522_0.jpg The event, which was open to CHLA’s clinical research personnel, postdocs, students, faculty and other staff, brought together twenty-five unique resource representatives from CHLA and the Southern California Clinical and Translational Science Institute (SC CTSI). For two hours... Read More

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