Research News Listing

Published on September 12, 2016
Perrin resized.jpg In a first-of-its-kind look at human kidney development, researchers at The Saban Research Institute of Children’s Hospital Los Angeles have isolated human nephron progenitor (NP) cells.  Their results, published online in the journal Stem Cell Translational Medicine, will... Read More
Published on September 1, 2016
21386-chla-placeholders_320x165_v2_0.jpg Co-occurrences could have broad clinical implications for patient care over a lifetime Researchers at the Institute for the Developing Mind at Children’s Hospital Los Angeles have analyzed current gene-disease findings to understand why people with neurodevelopmental and... Read More
Published on August 30, 2016
human Teli-1  web.jpg A research team led by investigators at The Saban Research Institute of Children’s Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells. Tissue-engineered Liver (TELi) was found to contain normal structural... Read More
Published on August 17, 2016
Leo Mascarenhas, MD.jpg In an innovative, first-in-pediatrics study, available only at Children’s Hospital Los Angeles (CHLA), researchers will be enrolling children between 1 and 18 years of age who have certain types of relapsed or treatment-resistant cancer. The aim of this investigator-initiated... Read More
Published on August 15, 2016
21386-chla-placeholders_320x165_v2_0.jpg Study suggests substantial complications may impact daily activities, long after initial cancer diagnosis A team of researchers from nine leading academic hospitals and research centers have published a paper in the early online edition of the journal Cancer that describes... Read More
Published on August 2, 2016
E44 PPARgamma meninges 63x zoom2.jpg Study shows why glucose levels are reduced in the brains of children with E. coli K1 meningitis Escherichia coli K1 (E. coli K1) continues to be a major threat to the health of young infants.  Affecting the central nervous system, it causes neonatal meningitis by... Read More
Published on July 27, 2016
St Baldrick's Foundation.jpg Five physician-researchers with the Center for Childhood Cancer and Blood Diseases at Children’s Hospital Los Angeles (CHLA) have been awarded more than $800,000 in grants from the St. Baldrick’s Foundation, the largest private funder of childhood cancer research. ... Read More
Published on July 27, 2016
J%20Bender%20Headshot2.jpg A study led by researchers at The Saban Research Institute of Children’s Hospital Los Angeles (CHLA) suggests that maternal HIV infection influences the microbiome of their HIV-uninfected infants.  Their findings, reported online in the journal Science Translational... Read More
Published on July 25, 2016
SALINAS,%20DANIELI.jpg A study by researchers at Children’s Hospital Los Angeles (CHLA), Brigham and Women’s Hospital and the California Department of Public Health suggests that all babies with a known mutation for cystic fibrosis (CF) and second mutation called the 5T allele should receive... Read More
Published on July 8, 2016
Michele Kipke PhD, and Thomas Buchanan, MD web.jpg Clinical and Translational Science Award will be Catalyst for Clinical and Community Research On June 30, 2016, a team of researchers led by Thomas Buchanan, MD, Michele Kipke PhD and Jonathan Samet, MD, of the Keck School of Medicine of the University of Southern California... Read More
Published on June 20, 2016
Pat Levitt, PhD.jpg Researchers at The Saban Research Institute of Children’s Hospital Los Angeles have identified a new genetic candidate for testing therapies that might affect fear learning in people with PTSD or other conditions. Results of the study have been published in the Journal of... Read More
Published on June 14, 2016
Neurons in the hypothalamus develop abnormally in Prader-Willi Syndrome - web.jpg A study published in the journal Human Molecular Genetics by researchers at Children’s Hospital Los Angeles (CHLA) provides novel insights into the brain mechanisms underlying the insatiable hunger and subsequent obesity in patients with Prader-Willi syndrome. Prader-Willi... Read More
Published on June 13, 2016
T Grikscheit web.jpg Tracy C. Grikscheit, MD, pediatric surgeon and principal investigator at The Saban Research Institute of Children’s Hospital Los Angeles, treats a large number of young patients who require surgery for various intestinal diseases.  Since the intestinal microbiome is an... Read More
Published on June 7, 2016
SALINAS,%20DANIELI.jpg Screening of thousands of children in California suggests which mutations are disease-causing and which are benign When it comes to cystic fibrosis (CF), more than 2,000 different genetic mutations have been reported.  However, only 200 of them have been categorized –... Read More
Published on May 4, 2016
Untitled 3.jpg Vicente Gilsanz, MD, PhD, has been named the 2016 Presidential Recognition Award winner by the Society for Pediatric Radiology.  The award recognizes his contributions to the Society and the specialty of pediatric radiology, including his accomplishments in imaging research... Read More
Published on April 14, 2016
Retinoblastoma tumor cells, web.jpg Use of Chemotherapy with a Survivin Inhibitor Improves Treatment Responses in Retinoblastoma Cells and Ocular Tumor Models Researchers at The Saban Research Institute of Children’s Hospital Los Angeles (CHLA) have demonstrated that targeting survivin – a protein that inhibits... Read More
Published on April 11, 2016
Stem cell-derived retina, web.jpg Study seeks to improve understanding of light-sensitive cells in the retina that initiate daylight vision David E. Cobrinik, MD, PhD, of The Vision Center at Children’s Hospital Los Angeles (CHLA) has been awarded a four-year grant totaling $1.665 million from the National... Read More
Published on April 5, 2016
Frey_sheddingCells, web.jpg The lining of the intestine is the most rapidly-renewing tissue in the body. Routine shedding of epithelial cells from this lining is a key element of tissue turnover, and is thus essential to maintaining optimal health. Altered shedding is associated with multiple disorders,... Read More
Published on March 29, 2016
21386-chla-placeholders_320x165_v2_0.jpg Phase 1/Phase 2 study offers major new approach to treating cancer The Children’s Center for Cancer and Blood Diseases (CCCBD) at Children’s Hospital Los Angeles is one of the first sites in the world to offer a promising new investigational therapy to treat pediatric acute... Read More
Published on March 24, 2016
MontageCellReportCHLA_PR-T 50% web.jpg A new study led by researchers at The Saban Research Institute of Children’s Hospital Los Angeles (CHLA) reports that the presence of leptin – a hormone secreted by fat cells that is critical to maintaining energy balance in the body -- inhibits the prenatal development of... Read More

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