Research News Listing

Published on December 2, 2015
134410014607_0.jpg Dr. Joe Church, shown with patient Cristina Jade Peña in 1994.  Today, at age 31, Cristina is leading “a wonderful and happy life, because of medical advancements, and the lifesaving care and treatment by Dr. Church and his team at CHLA.”Joseph Church, MD, has a thick stack of... Read More
Published on December 1, 2015
134368525396_0.jpg Individuals with autism spectrum disorder (ASD) often have difficulty recognizing and interpreting how facial expressions convey various emotions – from joy to puzzlement, sadness to anger.  This can make it difficult for an individual with ASD to successfully navigate social... Read More
Published on November 30, 2015
facial expressions.jpg Individuals with autism spectrum disorder (ASD) often have difficulty recognizing and interpreting how facial expressions convey various emotions – from joy to puzzlement, sadness to anger.  This can make it difficult for an individual with ASD to successfully navigate... Read More
Published on November 19, 2015
133562077511.jpg Birth of a NeuronWhat can the developing brain, specifically the birth of neurons (green), tell us about predisposition to childhood obesity and diabetes? Researchers at Children’s Hospital Los Angeles, led by Sebastien Bouret, PhD, are investigating how neuron development in... Read More
Published on November 9, 2015
132883476530_0.jpg More children are surviving malignant brain tumors than in the past, thanks to intense treatments using platinum-based chemotherapy. Unfortunately, the therapy has a known side effect of permanent hearing loss, resulting from damage to the inner ear. Investigators at Children’s... Read More
Published on November 3, 2015
ORGEL, ETAN 2.jpg More children are surviving malignant brain tumors than in the past, thanks to the use of intense treatments using platinum-based chemotherapy (cisplatin and high-dose carboplatin).  Unfortunately, the therapy has a known side effect of permanent hearing loss,... Read More
Published on October 30, 2015
132220765087_0.jpg Decreased lung development often occurs in babies born prematurely. Known as bronchopulmonary dysplasia, the condition is linked to decreased numbers of specialized lung cells known as lipofibroblasts (LIF). Here, researchers at Children’s Hospital Los Angeles demonstrate how... Read More
Published on October 28, 2015
132089727532_0.jpg Left: Untreated cancer cells. Right: Cells treated with the nanoparticle complex HerMn, which is cytotoxic to tumor cells (disrupting the cytoskeleton and structure of these cells as shown above) while simultaneously enhancing MRI contrast. Image courtesy of Karn Sorasaenee, PhD... Read More
Published on October 15, 2015
131253803464_0.jpg Most babies are leaving their mark on mothers, detectable even after birth, in the form of fetal cells left behind after pregnancy. Image courtesy of Shutterstock.A recent study published in Molecular Human Reproduction reports evidence of fetal cells escaping the womb and... Read More
Published on October 14, 2015
131161740592_0.jpg Researchers use MRS imaging to study effects of hypothermia for infants with decreased oxygen to the brainCHLA’s team of nurses and medical professionals administer hypothermia treatments to newborns to prevent brain damage caused by an inhibited oxygen supply to the brain.... Read More
Published on October 10, 2015
130908835124_0.jpg How natural killer immune cells can fight cancerNatural killer (NK) immune cells can identify infected or potentially cancerous cells in the body and induce cell death. Image courtesy of Shutterstock.Cancer cells present a unique challenge to the immune system in that they are... Read More
Published on October 8, 2015
hypothermia team.jpg Latest study shows effects of hypothermia on infant brain metabolism using MRS imaging A unique study at Children’s Hospital Los Angeles of newborns treated with hypothermia for hypoxic-ischemic encephalopathy (HIE) – a condition that occurs when the brain is deprived of an... Read More
Published on October 7, 2015
130696397782_0.jpg Tissue-engineered colon generated from cells from a patient with Hirschsprung’s disease. Nerve cells shown in green. Image courtesy of Grikscheit Laboratory, The Saban Research Institute, CHLA.A study by scientists at Children’s Hospital Los Angeles has shown that tissue-... Read More
Published on October 5, 2015
130571636638_0.jpg Neural dysfunction in cognitive control circuits during adolescence could be predictor of psychotic disordersThose at clinically high risk (CHR) for psychotic disorders on average had lower levels of conflict-related brain activity compared to healthy controls (HC). VS = ventral... Read More
Published on October 1, 2015
130297490576_0.jpg In a new study published in the journal Pediatric Emergency Care, investigators at Children’s Hospital Los Angeles piloted a brief mental health screening tool to be used with patients accessing the emergency department for medical complaints who might be at risk for mental... Read More
Published on October 1, 2015
TE Colon_Grik 50%.jpg A study by scientists at Children’s Hospital Los Angeles has shown that tissue-engineered colon derived from human cells is able to develop the many specialized nerves required for function, mimicking the neuronal population found in native colon. These specialized neurons,... Read More
Published on October 1, 2015
11_17_14 ED photo 10%.jpg In a study to be published on Oct.1 by the journal Pediatric Emergency Care, investigators at Children’s Hospital Los Angeles piloted a brief mental health screening tool to be used with patients accessing the emergency department for medical complaints who might be at risk... Read More
Published on September 30, 2015
130240363522_0.jpg Children’s Hospital Los Angeles Awarded $8 Million as Part of Landmark NIH Study to Find the AnswerAs part of a landmark study about the effects of adolescent substance use on the developing brain called the Adolescent Brain Cognitive Development (ABCD) study, Children’s... Read More
Published on September 30, 2015
Newsroom.jpg Study on substance use and adolescent brain development to look at 10,000 children at research institutions throughout the U.S. As part of a landmark study about the effects of adolescent substance use on the developing brain called the Adolescent Brain Cognitive Development... Read More
Published on September 28, 2015
130103254855_0.jpg The gastrointestinal (GI) tract, which includes the stomach and intestines, is controlled by the enteric nervous system (ENS), which functions almost like a “second brain” controlling the movement of food throughout the tract and its digestion. The ENS is embedded within the GI... Read More

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