Research News Listing

Published on July 7, 2020
Hero_Donuts.png Weight gain is a necessary part of any healthy pregnancy. But failure to lose this weight after the baby is born, or gaining additional weight after delivery, can be detrimental to a woman’s health. Obesity rates in the United States continue to rise, and women who do not... Read More
Published on June 29, 2020
CHLA-Blog-Pediatric-Guidelines-Venous-Access-1200x628-01.jpg Will make the process better, safer and more cost efficient By Ellin Kavanagh   Placement of an intravenous catheter—to allow health care providers the ability to easily take blood or administer medications—is one of the most common inpatient procedures. Although... Read More
Published on June 17, 2020
GettyImages-1124674521.jpg Using single-cell sequencing, investigators mapped the various stages of T-cell development in the human thymus LOS ANGELES (Jun. 16, 2020) — Chintan Parekh, MD, of the The Saban Research Institute of Children’s Hospital Los Angeles, has led a team of... Read More
Published on June 17, 2020
Dr. Peterson _0008.jpg By Melinda Smith Now more than ever, we understand that the prenatal period represents a crucial time of brain development. Maternal drug use during this period has been shown to lead to poor developmental outcomes for the child. A new study published in JAMA Pediatrics... Read More
Published on June 3, 2020
CHLA-COVID19-Research-Chang-1200x628-01.jpg Todd P. Chang, MD, MAcM, Attending Physician, Division of Emergency and Transport Medicine In the face of the COVID-19 pandemic, changes must be made to how patients are resuscitated. Normal procedures such as intubation and CPR can allow viruses to spread.  The American... Read More
Published on June 2, 2020
CHLA-COVID19-Research-Bard-1200x628-01.jpg Jennifer Dien Bard, PhD and Xiaowu Gai, PhD, Department of Pathology and Laboratory Medicine Patients of different ages and ethnicities, from a range of geographic locations, have been exhibiting varying types of illness and symptom severity due to COVID-19. While children... Read More
Published on June 1, 2020
CHLA-COVID19-Research-Espinoza-1200x628-01.jpg Juan Espinoza, MD, Attending Physician, General Pediatrics COVID-19 has required changes in every level of patient care as the nation strives to maintain safe intrapersonal distance. One way Children’s Hospital Los Angeles has addressed this issue is through the development... Read More
Published on May 31, 2020
CHLA-COVID19-Research-Khemani-1200x628-01.jpg Robinder Khemani, MD, and Christopher Newth, MD, Attending Physicians, Division of Critical Care Medicine  In the most severe cases of COVID-19, patients suffer from acute respiratory distress syndrome (ARDS), which can be fatal. Ventilator management in ARDS... Read More
Published on May 30, 2020
CHLA-COVID19-Research-Neely-1200x628-01.jpg Michael Neely, MD, MSc, Chief, Division of Infectious Diseases Early reports suggested that hydroxychloroquine (HCQ), a drug used to prevent malaria and treat children with certain rheumatologic conditions like lupus, may relieve inflammation associated with moderate or... Read More
Published on May 29, 2020
CHLA-COVID19-Research-Precit-1200x628-01.jpg Mimi Precit, PhD, Postdoctoral Researcher, Department of Pathology and Laboratory Medicine To fight a disease that is affecting the entire world, the disease must be better understood. Scientists and clinicians need data about the disease spectrum, optimal sample types for... Read More
Published on May 28, 2020
CHLA-COVID19-Research-Shi-1200x628-01.jpg Wei Shi, MD, PhD, Investigator, Developmental Biology/Stem Cells/Tissue Engineering COVID-19 is caused by the novel coronavirus, SARS-CoV-2, infecting the respiratory system. Specifically, the spike protein (S1 subunit) of the virus binds to a protein receptor called... Read More
Published on May 27, 2020
CHLA-COVID19-Research-Szymanski-1200x628-01.jpg Linda Szymanski, DO, Neuropathologist, Director, Autopsy and Perinatal Pathology Since the onset of the COVID-19 pandemic, scientists and clinicians have sought to better understand the virus and how it spreads. Analysis of antibodies developed against the... Read More
Published on May 26, 2020
CHLA-COVID19-Research-Yau-1200x628-01.jpg Ji-Ting Janet Yau, DO, General Pediatrics Resident The COVID-19 pandemic is a major stressor in the lives of the global community, but perhaps greatest for adolescents and young adults, who don’t always have resources to help them cope. To assess psychosocial stress... Read More
Published on May 22, 2020
Grikscheit engineered intestine.png Intestine grown from stem cells in Dr. Grikscheit’s laboratory. Children’s Hospital Los Angeles surgeon achieves milestone in using tissue engineering to grow complete gut nervous system. ​​ Babies with Hirschsprung’s disease are born with an... Read More
Published on May 22, 2020
Grikscheit engineered intestine.png Children’s Hospital Los Angeles surgeon achieves milestone in preclinical research for Hirschsprung’s Disease  By Melinda Smith The human body has what is sometimes called a “second brain” in the digestive tract. The enteric nervous system (ENS) performs many vital... Read More
Published on May 1, 2020
CHLA-Blog-Sowell-Thumbnail-400x210-01.jpg Elizabeth Sowell, PhD Adolescence is a time of great change, both emotionally, socially and physically. To understand how these changes affect the health of our nation’s children as they develop, the National Institutes of Health (NIH) has funded the... Read More
Published on March 31, 2020
Leukemia_Hero.png CHLA scientists work toward a new therapy to target resistant leukemia.  In CAR-T therapy, a patient’s own immune system cells—called T-cells—are isolated and genetically modified to recognize CD-19, a protein (antigen) found on leukemia cells. A few years ago, this... Read More
Published on February 28, 2020
183313552487_0.jpg They wear lab coats in place of capes, safety goggles instead of masks, and wield pipets - not swords. But they are still our heroes.Feb 11th was International Day of Women and Girls in Science, and March 8th is International Women's Day. Did you know that more than half of... Read More
Published on February 20, 2020
Dr Wu transport.jpg LOS ANGELES (Feb. 20, 2020) — When a newborn suffers lack of oxygen before or during birth, doctors have very little time to save precious brain tissue. The only proven effective way to treat babies with hypoxic brain injuries is by reducing body temperature through controlled... Read More
Published on February 12, 2020
CHLA-Michael-Goran-4.jpg LOS ANGELES (Feb. 12, 2020) — Maternal factors, such as breast milk, have been shown to affect a baby’s development, and previous animal studies have determined that a carbohydrate, the oligosaccharide 2’FL found in maternal milk, positively influences neurodevelopment. Now, in... Read More