Research News Listing

Published on October 2, 2018
CHLA-Marachelian-Araz-782.jpg Combining a new, targeted drug with chemotherapy shows promise in children with advanced disease A phase 2 clinical trial has found that combining a novel compound called alisertib with chemotherapy has anti-tumor activity in children with high-risk, relapsed neuroblastoma.... Read More
Published on September 21, 2018
CHLA-Lee-Helman-782x439.jpg Lee Helman, MD, of Children’s Hospital Los Angeles, is a founding members of a novel cancer consortium announced at the Biden Summit on Sept. 21, 2018 Former Vice President Joe Biden and Dr. Jill Biden hosted the national Biden Cancer Summit, on Sept. 21, to highlight the... Read More
Published on September 19, 2018
21386-chla-placeholders_320x165_v2_0.jpg Investigator at Children’s Hospital Los Angeles Awarded $2.3 Million to Study Bone Loss Associated with Cerebral Palsy   Cerebral palsy (CP) is the most common physical disability originating in childhood. Approximately 2 of every 1000 babies born acquire this... Read More
Published on September 19, 2018
developing retina (2).jpg Finding in retinoblastoma could lead to new interventions Investigators at Children's Hospital Los Angeles have been able to pinpoint the exact stage of development of the human retina, when cells can grow out of control and form cancer-like masses. The finding could open the... Read More
Published on August 23, 2018
21386-chla-placeholders_320x165_v2_0.jpg CHLA investigators spotlight the need to include obese and overweight subjects in metabolic research to prevent potentially misleading outcomes.   Children's Hospital Los Angeles investigators have demonstrated the need to include a growing constituency of obese and... Read More
Published on June 27, 2018
heart.png CHLA and USC researchers team up to design and implant a minimally-invasive device in area around the heart.   Investigators at Children's Hospital Los Angeles and the University of Southern California have demonstrated the feasibility of implanting a... Read More
Published on June 22, 2018
Pat Levitt, PhD.jpg Children's Hospital Los Angeles contributes to large, multisite international ‘Brainstorm’ Project   Investigators found that many common psychiatric disorders are deeply connected on a genetic level, sharing specific genetic risk factors, underscoring the need to... Read More
Published on June 20, 2018
Third_Day_of_Chemo_day_before_Discharge_12042017-copy.jpg “We thought she had a bug bite,” says Michelle’s mom, “but it turned out to be cancer.” After seeing several doctors, the family was referred to Children’s Hospital Los Angeles. Because the team of specialists at CHLA had access to a specialized genetic test that they helped... Read More
Published on June 18, 2018
CureWorks_logo_w_tag_TM_jpg.jpg Seattle Children’s, with participating members Children’s Hospital Los Angeles, Children’s National Health System and BC Children’s Hospital, has launched CureWorks, an international collaborative of leading academic children’s hospitals determined to accelerate the development... Read More
Published on May 24, 2018
Levitt_Pat 5-sm.jpg LOS ANGELES -- Pat Levitt, PhD, has been named Vice President, Chief Scientific Officer and Director of The Saban Research Institute of Children’s Hospital Los Angeles. “In addition to being a distinguished scholar and brilliant scientist, Dr. Pat Levitt’s commitment to... Read More
Published on May 16, 2018
10E4_CHLA90_2[2] (tumor-associated macrophages) Findings suggest new therapeutic approach for children with high-risk disease Investigators at the Children’s Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles provide preclinical evidence that the presence of tumor-associated macrophages—a type of... Read More
Published on May 16, 2018
MRI of brain (1).jpg Investigators at Children’s Hospital Los Angeles have determined that in children receiving gadolinium as a contrast agent to enhance MRI examinations, signal changes attributed solely to deposition of this material in the brain are not dependent on the amount of gadolinium... Read More
Published on February 28, 2018
Etan Orgel.jpg Less-toxic lymphoid regimens are more likely to obtain remission in mixed phenotype acute leukemia (MPAL) A study at Children’s Hospital Los Angeles is shedding new light on the best therapeutic approach for a rare and aggressive leukemia called mixed phenotype acute... Read More
Published on February 27, 2018
CHLA-Bradley-Peterson.jpg Stress and other factors can trigger immune response A landmark study published in the Journal of Neuroscience on February 26 reveals that activation of a pregnant mother’s immune system can affect her baby’s brain development. A team of researchers led by Bradley Peterson,... Read More
Published on February 21, 2018
LM.jpg Children’s Hospital Los Angeles one of 25 sites in international study of larotrectinib Three quarters of patients, both adults and children, with a variety of advanced cancers occurring in different sites of the body responded to larotrectinib, a novel therapy that targets a... Read More
Published on February 5, 2018
Jasmine_HLHS Consortium web.jpg Children's Hospital Los Angeles is announcing participation in the first-ever clinical trial using stem cells from umbilical cord blood to delay or even prevent heart failure in children born with a rare congenital heart defect that leaves them with half a heart. The Phase I... Read More
Published on February 1, 2018
Michael  Pulsipher, MD, CHLA3.jpg Detailed analysis of patient data now available Results of the global, multicenter, pivotal phase 2 study that led to the first FDA approval of a gene therapy/cell therapy approach known as CAR T-cell therapy, were published on January 31 in the New England Journal of... Read More
Published on December 14, 2017
Laura Perin, PhD_0 (1) 2017 web.jpg Study findings indicate a more effective way to slow organ damage in Alport syndrome Researchers have demonstrated for the first time that extracellular vesicles – tiny protein-filled structures – isolated from amniotic fluid stem cells (AFSCs) can be used to effectively... Read More
Published on November 20, 2017
CHLA-D.Brent Polk, MD.jpg Findings may point to new treatment approaches for patients with IBD D. Brent Polk, MD, AGAF, an investigator at Children’s Hospital Los Angeles, has been awarded $1.5 million by the National Institute of Diabetes and Digestive and Kidney Diseases of the NIH for the study of... Read More
Published on November 13, 2017
CHLA-St. Baldrick's Foundation check presentation at CHLA.jpg Three physician-researchers with the Children’s Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles (CHLA) have been awarded more than $1 million in grants from the St. Baldrick’s Foundation, the largest private funder of childhood cancer research. The... Read More

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