Madrid Medicine School/Spain
Montefiore Medical Center/New York: Rotating Internship
Mayo Graduate School of Medicine: Internal Medicine Residency; Children's Hospital Boston: Pediatric Radiology Residency; Mount Sinai Hospital/New York: Radiology Residency
Internal Medicine: American Board of Internal Medicine; Pediatric Radiology: American Board of Radiology; Diagnostic Radiology: American Board of Radiology
Adiposity in children and adolescents: correlates and clinical consequences of fat stored in specific body depots. Katzmarzyk PT, Shen W, Baxter-Jones A, Bell JD, Butte NF, Demerath EW, Gilsanz V, Goran MI, Hirschler V, Hu HH, Maffeis C, Malina RM, Müller MJ, Pietrobelli A, Wells JC. Pediatr Obes. 2012 Oct;7(5):e42-61. doi: 10.1111/j.2047-6310.2012.00073.x. Epub 2012 Aug 21.
Racial Disparity in Fracture Risk between White and Nonwhite Children in the United States.
Wren TA, Shepherd JA, Kalkwarf HJ, Zemel BS, Lappe JM, Oberfield S, Dorey FJ, Winer KK, Gilsanz V. J Pediatr. 2012 Sep 10. pii: S0022-3476(12)00879-7. doi: 10.1016/j.jpeds.2012.07.054.
MRI-measured pelvic bone marrow adipose tissue is inversely related to DXA-measured bone mineral in younger and older adults. Shen W, Chen J, Gantz M, Punyanitya M, Heymsfield SB, Gallagher D, Albu J, Engelson E, Kotler D, Pi-Sunyer X, Gilsanz V. Eur J Clin Nutr. 2012 Sep;66(9):983-8. doi: 10.1038/ejcn.2012.35. Epub 2012 Apr 11.
Brown adipose tissue and its relationship to bone structure in pediatric patients. Ponrartana S, Aggabao PC, Hu HH, Aldrovandi GM, Wren TA, Gilsanz V. J Clin Endocrinol Metab. 2012 Aug;97(8):2693-8. Epub 2012 May 16.
Inverse association between brown adipose tissue activation and white adipose tissue accumulation in successfully treated pediatric malignancy. Chalfant JS, Smith ML, Hu HH, Dorey FJ, Goodarzian F, Fu CH,Gilsanz V. Am J Clin Nutr. 2012 May;95(5):1144-9. Epub 2012 Mar 28.
The depiction of brown adipose tissue is related to disease status in pediatric patients with lymphoma.Gilsanz V, Hu HH, Smith ML, Goodarzian F, Carcich SL, Warburton NM, Malogolowkin M. AJR Am J Roentgenol.2012 Apr;198(4):909-13.
Unequivocal identification of brown adipose tissue in a human infant. Hu HH, Tovar JP, Pavlova Z, Smith ML,Gilsanz V. J Magn Reson Imaging. 2012 Apr;35(4):938-42. doi: 10.1002/jmri.23531. Epub 2011 Dec 16.
Changes in brown adipose tissue in boys and girls during childhood and puberty. Gilsanz V, Smith ML, Goodarzian F, Kim M, Wren TA, Hu HH. J Pediatr. 2012 Apr;160(4):604-609.e1. Epub 2011 Nov 1.
Optimal monitoring time interval between DXA measures in children. Shepherd JA, Wang L, Fan B, Gilsanz V, Kalkwarf HJ, Lappe J, Lu Y, Hangartner T, Zemel BS, Fredrick M, Oberfield S, Winer KK. J Bone Miner Res. 2011 Nov;26(11):2745-52. doi: 10.1002/jbmr.473.
Revised reference curves for bone mineral content and areal bone mineral density according to age and sex for black and non-black children: results of the bone mineral density in childhood study. Zemel BS, Kalkwarf HJ, Gilsanz V, Lappe JM, Oberfield S, Shepherd JA, Frederick MM, Huang X, Lu M, Mahboubi S, Hangartner T, Winer KK. J Clin Endocrinol Metab. 2011 Oct;96(10):3160-9. Epub 2011 Sep 14.
Reduced bone mineral density leads to osteoporosis, resulting in bones becoming increasingly brittle and at risk for fracture. With the cost of treatment in 2010 estimated at $10 billion, osteoporosis is a significant public health issue that affects 55 percent of Americans age 50 and older. The 2000 National Institutes of Health Consensus Development Conference on Osteoporosis Prevention, Diagnosis, and Therapy identified bone mineral deposition during adolescence as a critical determinant of osteoporosis risk later in life. The care of patients with osteoporosis is difficult, and most therapies increase bone density by small amounts, yet require long periods of treatment. In contrast, during puberty large increases in bone density occur over a short period of time.
Puberty is a time of significant bone development and during this time, bones grow and increase in density. At the end of puberty, the epiphyseal plates close, terminating the ability of the bones to lengthen. When that occurs, the teenager has reached his or her maximum height and, soon after, peak bone mass. By employing sensitive instruments for measuring bone mass at the beginning of puberty, Gilsanz and his colleagues can extrapolate what a teenager’s peak bone mass will be at the end of puberty. Using this information, they can potentially identify adolescents at risk for decreased bone density at the beginning of puberty, when there is still time to intervene and take advantage of the tremendous deposition of bone that occurs before puberty ends.
Visit the Gilsanz Laboratory.
- National Institute of Health (NIH)
- Associate and Affiliate Groups at Children's Hospital Los Angeles