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Tracy Grikscheit, MD is an attending surgeon and associate professor of surgery at Children’s Hospital Los Angeles. Her past research and current interests are centered on engineering solutions for a congenital and acquired intestinal deficit which has been reported in numerous peer-review journals and national and international presentations. Dr. Grikscheit is a funded primary investigator conducting research at The Saban Research Institute.
Clinical Interests
Surgery of Infancy and Childhood; Neonatal Surgery; Solid Tumors in Children; Congenital Anomalies
Education
Columbia University College of Physicians & Surgeons
Massachusetts General Hospital: General Surgery
Massachusetts General Hospital: General Surgery
Seattle Children's Hospital and Regional Medical Center: Pediatric Surgery; Research Fellow Department of Surgery Massachusetts General Hospital for Children
Accomplishments
Surgery, American Board of Surgery
Pediatric Surgery, American Board of Surgery
American College of Surgeons (ACS)
American Academy of Pediatrics (AAP)
Society of University Surgeons (SUS)
American Pediatric Surgical Association (APSA)
Association for Academic Surgery (AAS)
Tracy Grikscheit, MD, is a practicing pediatric surgeon and scientist with a laboratory focused on regenerative medicine and tissue engineering at The Saban Research Institute of Children's Hospital Los Angeles. In the hospital, she cares for children who are born prematurely, and therefore are at increased risk for multiple medical conditions that may lead to intestinal lack or loss. One of these conditions is necrotizing enterocolitis (NEC), a potentially life-threatening intestinal problem. For the most severe cases of NEC, the only solution is surgical removal of the small intestine. However, this option leaves the baby dependent on intravenous feeding and the child is also at risk for liver damage from subsequent intravenous nutrition. Another option is small bowel transplantation, but graft and patient survival rates are still too low. Dr. Grikscheit envisions a better solution. The small intestine is an exquisitely regenerative organ. It is an elegant model to better understand organ-specific stem cells and the regenerative cells can be harnessed to make new gastrointestinal tissue for eventual clinical applications. Understanding how to generate tissue-engineered intestines, whether esophagus, stomach, small intestine, or colon, may also inform us how to expand the list of organs that can be tissue-engineered.
Visit the Grikscheit Laboratory.
Medical News Today- Baby’s Breath: A New Way to Study Neonatal Lung Disease
Nature — Deriving human ENS lineages for cell therapy and drug discovery in Hirschsprung disease
GenEn News- Tissue-engineered colon from human cells develop different types of neurons
CNBC- First Step: From Human Cells to Tissue-Engineered Esophagus
Science Daily- Functional liver tissue grown from adult stem, progenitor cells
ScienceBlog- Scientists develop tissue-engineered model of human lung and trachea
Science Daily - Scientists develop tissue-engineered model of human lung and trachea
Newsweek- The Race to Grow New Organs
CHLA Blog
Baby’s Breath: A New Way to Study Neonatal Lung Disease
Tissue-Engineered Colon from Human Cells Develop Different Types of Neurons
Zebrafish Provide a Novel Model to Study Short Bowel Syndrome
First Step: From Human Cells to Tissue-Engineered Esophagus
Engineering "Replacement Parts"
Born With a Hole in Her Diaphragm, Magnolia Hope Is Thriving