Staff Hematopathologist
  • Summary
  • Publications
  • Research
  • Locations

Dr. Matthew Oberley is a Hematopathologist and the Director of the Bone Marrow Laboratory and the Associate Director of the Hematology Laboratory at Children's Hospital Los Angeles. He holds an Assistant Professor of Clinical Pathology appointment at the Keck School of Medicine of the University of Southern California. He is responsible for diagnostic signout of bone marrows, lymph nodes, hematologic malignancy, fluids, flow cytometry, immunology, minimal residual disease testing by flow cytometry, chromosomal microarrays, and FISH at CHLA. His research focuses on pediatric leukemia, minimal residual disease, and non-Hodgkin lymphoma.

Clinical Interests

Hematopathology, Anatomic Pathology, Molecular Pathology, Laboratory Medicine

Education

Medical School: 

University of Wisconsin, Madison

Graduate School: 

University of Wisconsin, Madison (PhD)

Residency: 

University of Wisconsin Hospital and Clinics, Madison (Anatomic and Clinical Pathology)

Fellowship: 

University of Wisconsin Hospital and Clinics, Madison (Hematopathology)

Accomplishments

Certification: 

American Board of Pathology: Anatomic and Clinical Pathology and Hematology

Professional Memberships: 

American Society for Clinical Pathology
College of American Pathology
Society for Hematopathology
American Society of Hematology
International Clinical Cytometry Society
Children's Oncology Group
Society for Pediatric Pathology

Awards: 

Resident/Fellow Presentation Award, Michael N. Hart Research Day (2013)
Travel Award, College of American Pathologists Policy Meeting (2011)
Ruth L. Kirschstein National Research Service Award, NCI (2003-04)
National Research Service Award, NIH (2001-03)
Predoctoral Training Grant Award, NIH (1998-2000)

Publications: 

Oberley MJ, Gaynon PS, Bhojwani D, Pulsipher MA, Gardner RA, Hiemenz MC, Ji J, Han J, O’Gorman MRG, Wayne AS, Raca G. Myeloid Lineage Switch Following Chimeric Antigen Receptor T-cell Therapy in a Patient with TCF3-ZNF384 Fusion-Positive B-Lymphoblastic Leukemia. Pediatric Blood and Cancer. 2018. PMID: 29797659

Denton CC, Rawlins YA, Oberley MJ, Bhojwani D, Orgel E. Predictors of hepatotoxicity and pancreatitis in patients with acute lymphoblastic leukemia treated according to Children’s Oncology Group regimens. Pediatric Blood and Cancer. 2018; 65. PMID: 29218844

Maruffi M, Sposto R, Oberley MJ, Kysh L, Orgel E. Therapy for children and adults with mixed phenotype acute leukemia: A systematic review and meta-analysis. Leukemia. 2018; 32: 1515-1528. PMID: 29550836

Martin A, Tu N, Duncan K, Oberley M, Hochstim C. Primary pediatric lymphoma of the larynx: an unusual presentation of a rare histologic subtype. International Journal of Pediatric Otorhinolaryngology Extra. 2018; 19: 3-5.

Moke DJ, Oberley MJ, Bhojwani D, Parekh C, Orgel E. Association of clinical trial enrollment and survival in pediatric acute lymphoblastic leukemia. Pediatric Blood and Cancer. 2018; 65. PMID: 28876513

Oberley MJ, Denton C, Ji J, Hiemenz M, Bhojwani D, Ostrow D, Wu S, Gaynon P, Raca G. A Neoplasm with FIP1L1-PDGFRA Fusion Presenting as Pediatric T-cell Lymphoblastic Leukemia/Lymphoma without Eosinophilia. Cancer Genetics. 2017; 216: 91-99. PMID: 29025601

Roth L, O’Donohue T, Chen Z, Bartlett N, LaCasce A, Barth M, Davies K, Blum K, Christian B, Casulo C, Smith S, Termuhlen A, Oberley MJ, Alexander S, Weitzman S, Appel B, Mizukawa B, Svoboda J, Afify Z, Pauly M, Dave H, Gardner R, Stephens D, Link B, Forlenza C, Levine J, Williams M, Sima J, Bollard C, Leonard JP. Outcomes of Adults, Adolescents, and Children with Primary Mediastinal B-Cell Lymphoma Treated with Dose-Adjusted R-EPOCH Therapy: A Multicenter Retrospective Analysis. British Journal of Hematology. 2017; 179:739-747. PMID: 29082519

Sheng X, Parmentier J, Tucci J, Pei H, Cortez-Toledo O, Dieli-Conwright C, Oberley MJ, Neely M, Orgel E, Louie SG, Mittelman SD. Adipocytes sequester and metabolize daunorubicin. Molecular Cancer Research. 2017; 15:1704-1713. PMID: 29117945

Oberley MJ, Li S, Orgel E, Wei CP, Hagiya A, and O’Gorman MRG. Clinical significance of isolated myeloperoxidase expression in pediatric B-lymphoblastic leukemia. American Journal of Clinical Pathology. 2017; 147: 374-381. PMID: 28340210

Brennan MB, Herwaldt BL, Kazmierczak JJ, Weiss JW, Klein CL, Leith CP, He R, Oberley MJ, Tonnetti L, Wilkins PP, and Gauthier GM. Transmission of Babesia microti with Solid Organ Transplantation. Emerging Infectious Disease. 2016; 22 PMID: 27767010.

Moschiano E, Raca G, Fu C, Pattengale PK, Oberley MJ. Congenital B-lymphoblastic leukemia with a cryptic MLL rearrangement and post-treatment evolution to mixed phenotype acute leukemia. Leuk Res Rep. 2016; 6:29-32. PubMed PMID: 27547725.

Oberley MJ, Yang DT. Lymphoproliferative disorder with Auer rod–like inclusions. Blood. 2014; 124: 2607. PMID: 25513460.

Oberley MJ, Fitzgerald S, Morgan AS, Johnson J, Yang DT, and Leith C. Value Based Flow Testing of Chronic Lymphoproliferative Disorders: A Quality Improvement Project to Develop an Algorithm to Streamline Testing and Reduce Costs. American Journal of Clinical Pathology. 2014; 142: 411-8. PMID: 25125633.

Oberley MJ and Yang DT. Pure Erythroid Leukemia presenting in a HIV positive man. Clinical Lymphoma, Myeloma, and Leukemia. 2014; 14: e35-38. PMID: 24220619.

Oberley MJ, Rajguru SA, Zhang C, Kim KM, Shaw GR, Grindle KM, Kahl BS, Kanugh C,  Laffin J, and Yang DT. Immunohistochemical evaluation of MYC expression in mantle cell lymphoma. Histopathology. 2013; 63: 499-508. PMID: 23926923

Oberley MJ and Yang D. Laboratory testing for cobalamin deficiency in megaloblastic anemia. American Journal of Hematology. 2013; 88: 522-6. PMID: 23423840.

Xu X, Bieda M, Jin VX, Rabinovich A, Oberley MJ, Green R, and Farnham PJ. A comprehensive ChIP-chip analysis of E2F1, E2F4, and E2F6 in normal and tumor cells reveals interchangeable roles of E2F family members. Genome Research. 2007; 17:1550-61.

The ENCODE Project Consortium. Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007; 447: 799-816.

The ENCODE Project Consortium. The ENCODE (ENCylopedia Of DNA Elements) Project. Science. 2004; 306: 636-640.

Oberley MJ, Inman D, and Farnham PJ. E2F6 negatively regulates BRCA1 in human cancer cells without methylation of histone H3 on lysine 9. Journal of Biological Chemistry. 2003; 278:42466-76.

Weinmann AS, Yan PS, Oberley MJ, Huang TH, and Farnham PJ. Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis. Genes and Development. 2002; 16:235-244.

Zhu M, Chapman WG, Oberley MJ, Wasserman WW, and Fahl WE. Polymorphic electrophile response elements in the mouse glutathione S-transferase GSTa1 gene that confer increased induction. Cancer Letters. 2001; 164:113-8.

Oberley TD, Sempf JM, Oberley MJ, McCormick ML, Muse KE, Oberley LW. Immunogold analysis of antioxidant enzymes in human renal cell carcinoma. Virchows Archive. 1994; 424:155-64.

 

Research Interests: 

Pediatric leukemia

Minimal residual disease

Non-Hodgkin lymphoma

4650 Sunset Blvd.
Los Angeles, CA 90027