Director, Electron Microscopy, Experimental Pathology, and Biorepository
Attending Physician
Professor of Pathology (Clinical Scholar), Keck School of Medicine of USC
  • Summary
  • Publications
  • Research
  • Locations

Clinical Interests

  • Pediatric Pathology
  • Electron Microscopy
  • Renal Pathology
  • Neuroblastomas
  • Directed Electron Microscopy Laboratory for Diagnostic EM Services
  • Signed-out all the in-house Renal Pathology cases for both medical and transplant biopsies, and participated in weekly renal conference.
  • Responsible for all in-house neuroblastoma cases (diagnosing tumor tissues and BM biopsies), and presented cases at Surgery M-M Conferences.


Medical School: 

Yokohama City University School of Medicine


The Children's Hospital and Ohio State University


The Children's Hospital


  • California Medical Licensure
  • Physician's License - Japan
  • Autopsy Examiner - Japan
  • Registered Pathologist (Pathology Board) approved by Japanese Pathology Society
Professional Memberships: 

Society for Pediatric Pathology, United States and Canadian Academy of Pathology, Society of Ultrastructural Pathology, The New York Academy of Sciences, International Neuroblastoma Staging Society and Children's Oncology Group (Steering Committee)

  • Lotte Strauss Price from Society for Pediatric Pathology
  • Eleanor Humphrey's Visiting Professorship, University of Chicago
  • Visiting Professor, Department of Pediatric Surgery, Showa University School of Medicine, Tokyo, Japan
  • Honorary Fellow, The Royal College of Pathology of the Australiasia

Other Information


1: Wang LL, Teshiba R, Ikegaki N, Tang XX, Naranjo A, London WB, Hogarty MD, Gastier-Foster JM, Look AT, Park JR, Maris JM, Cohn SL, Seeger RC, Asgharzadeh S, and Shimada H: Highly Aggressive Neuroblastoma with Augmented Expression of MYCN or MYC Protein: A Children’s Oncology Group Study. Br J Cancer, in press DOI:10.1038/bjc.2015.188

2: Challagundla KB, Wise PM, Neviani P, Chava H, Murtadha M, Xu T, Kennedy R, Ivan C, Zhang X, Vannini I, Fanini F, Amadori D, Calin GA, Hadjidaniel M, Shimada H, Jong A, Seeger RC, Asgharzadeh S, Goldkorn A, Fabbri M. Exosome-Mediated Transfer of microRNAs Within the Tumor Microenvironment and Neuroblastoma Resistance to Chemotherapy. J Natl Cancer Inst. 2015 May 13;107(7). PubMed PMID: 25972604.

3: Grant CN, Mojica SG, Sala FG, Hill JR, Levin DE, Speer AL, Barthel ER, Shimada H, Zachos NC, and Grikscheit TC. Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive function. Am J Physiol Gastrointest Liver Physiol 308:G664-G677, 2015. PMID: 25573173

2: Wang LL, Suganuma R, Ikegaki N, Tang X, Naranjo A, McGrady P, London WB, Hogarty MD, Gastier-Foster JM, Look AT, Park JR, Maris JM, Cohn SL, Seeger RC, Shimada H: Neuroblastoma - Undifferentiated Subtype, Prognostic Significance of Prominent Nucleolar Formation and MYC/MYCN Protein Expression:A Report from the Children’s Oncology Group, Cancer 119:3718-3726, 2013, PMID: 23901000

5: Ikegaki N, Shimada H, Fox AM, Regan PL, Jacobs J, Kicks SL, Rappaport EF, Tang XX: Transient treatment with epigenetic modifiers yields stable neuroblastoma stem cells resembling aggressive large-cell neuroblastomas. Proc Natl Acad Sci USA 110:6097-6102, 2013 PMID: 23479628

Research Interests: 
  • Pathology of pediatric solid tumors
  • Pathology of peripheral neuroblastic tumors
  • Investigating biologically significant relationship between molecular/genetic alterations and their morphologic manifestations in peripheral neuroblastic tumors
  • Investigating molecular mechanism of invasion and metastasis in peripheral neuroblastic tumors
  • Developing computer-assisted program for the International Neuroblastoma Pathology Classification
  • Application of virtual microscopy to the neuroblastoma review

4650 Sunset Blvd.
MS 43
Los Angeles, CA 90027
Phone: 323-361-5813Office
Fax: 323-361-8005Fax