Beijing Medical University
Pathology Residency, Massachusetts General Hospital
Neuropathology, Massachusetts General Hospital
American Board of Pathology; Neuropathology
Tian D, Stoppel LS, Heynen AJ, Lindemann L, Jaeschke G, Mills AA, & Bear MF. (2015) Contribution of mGluR5 to pathophysiology in a mouse model of human chromosome 16p11.2 microdeletion (2015). Nat Neurosci. 18(2):182-4.
Tian D, Sun S, & Lee JT. The long noncoding RNA, Jpx, is a molecular switch for X-chromosome inactivation. Cell. 143(3):390-403, 2010.
Dickerson BC, Holzman D, Grant PE, & Tian, D. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. A 62-ear-old woman with seizure, gait disturbance and altered mental status. N Engl J Med. 353(21):2271-2280, 2005.
Warren HS Jr, Gonzalez RG, & Tian D. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. A 12-year-old girl with fever and coma. N Engl J Med. 349(24):2341-2349, 2003.
As a physician-scientist in the Department of Pathology and Laboratory Medicine and The Saban Research Institute, Tian conducts translational neuroscience research in the field of neurodevelopmental disorders (NDDs) using in vivo models and multidisciplinary approaches. The Tian Laboratory is interested in generating novel in vivo models of NDDs using genome editing technology; understanding the mechanism by which common and rare genetic abnormalities contribute to these disorders; and studying how epigenetic genes regulate brain development and functions. He employs a variety of experimental approaches, including genetics, biochemistry, electrophysiology, and behavioral analyses. His ultimate goal is to find the mechanisms for certain types of neurodevelopment disorders and to identify therapeutic targets.
Visit the Tian Laboratory.