Fetal Cardiology Research

Fetal Cardiology Program Research

The field of fetal cardiology is rapidly evolving due to cutting edge imaging technology and innovative new approaches to fetal therapy. The fetal cardiology program at Children's Hospital Los Angeles is dedicated to the pursuit of knowledge in the areas of prenatal diagnosis, fetal intervention, perinatal management and postnatal care of heart disease. We believe that our research can help forward the science of prenatal diagnosis and improve the care of our patients by increasing our understanding of both congenital heart disease (CHD) and acquired heart disease. Through our direct collaboration with our partners at USC perinatalogy, USC fetal therapy program and the USC School of Engineering, we can achieve novel insights and develop new technologies and therapies.

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We currently have ongoing research projects in all of the following areas of study. Below are samples of some recent publications from our institution in the field of fetal cardiology.

Prenatal Screening and Diagnosis of Congenital Heart Disease (CHD)

Votava-Smith JK, Glickstein JS, Simpson LL, Williams IA. Comparison of method of conception in fetuses undergoing echocardiography at a tertiary referral center. Prenat Diagn. 2014 Jan 16. [Epub ahead of print]

Sabati AA, Wong PC, Randolph L, Pruetz JD. Absent Aortic Valve Associated with Double Outlet Right Ventricle and Aortopulmonary Window: Physiologic Implications of a Rare Malformation in both the Fetus and the Neonate. Congenit Heart Dis. 2013 May 22.

Detterich J, Pruetz J, Sklansky MS. Color M-Mode Sonography for Evaluation of Fetal Arrhythmias. J Ultrasound Med. 2012 Oct;31(10):1681-8.

Pruetz JD, Detterich J, Trento L, Sklansky MS. Prenatal Diagnosis of Cor Triatriatum Sinister in a Fetus with Hypoplastic Left Heart Syndrome. Pediatr Cardiol. 2011 Aug;32(6):818-21.

Pruetz JD, Chmait RH, Sklansky MS. Complete Right Heart Flow Reversal: Pathognomonic Recipient Twin Circular Shunt in Twin-Twin Transfusion Syndrome. Journal of Ultrasound in Medicine, 28:1101-1106, August 2009.

Sklansky MS, Berman D, Pruetz JD, Chang RK. Prenatal Screening for Major Congenital Heart Disease: Superiority of Outflow Tracts Over the Four-Chamber View. Journal of Ultrasound in Medicine, 28:889-899, July 2009.

Kleinman CS, Glickstein JS, Krishnamurthy G, Votava-Smith JK. The Current Role of Fetal Echocardiography. In: Kleinman CS, Seri I, Polin RA (Eds). Hemodynamics and Cardiology: Neonatology Questions and Controversies, 2nd Ed. Philadelphia: Saunders Elsevier.

Kleinman CS, Glickstein JS, Krishnamurthy G, Votava-Smith JK. Fetal Echocardiography and Fetal Cardiology. In: Allen HD, Driscoll J, Shaddy RE, Feltes TF (Eds.) Moss and Adams’ Heart Disease in Infants, Children, and Adolescents: Including the Fetus and Young Adult, 8th Ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins.

Fetal Intervention and Therapy

Loeb GE, Zhou L, Zheng K, Nicholson A, Peck RA, Krishnan AA, Silka M, Pruetz J, Chmait R, Bar-Cohen . Design and testing of a percutaneously implantable fetal pacemaker. Ann Biomed Eng, 2013 Jan;41(1):17-27.

Villa CR, Habli M, Votava-Smith JK, Cnota JF, Lim FY, Divanovic AA, Wang Y, Michelfelder EC. Assessment of Fetal Cardiomyopathy in Early Stage Twin-Twin Transfusion Syndrome: Comparison between Commonly Reported Cardiovascular Assessment Scores. Villa CR, Habli M, Votava-Smith JK, Cnota JF, Lim FY, Divanovic AA, Wang Y, Michelfelder EC. Ultrasound Obstet Gynecol. 2013 Oct 21. [Epub ahead of print]

Jones K, Tierney K, Grubbs BH, Pruetz JD, Detterich J, Chmait RH Fetoscopic laser photocoagulation of feeding vessels to a large placental chorioangioma after fetal deterioration post amnioreduction.

Fetal Diagn Ther. 2012;31(3):191-5. Pruetz JD, Sklansky MS, Detterich J, Korst L, Llanes A, Chmait R. Twin-twin transfusion syndrome (TTTS) treated with laser surgery: postnatal incidence of heart disease in recipients and donors. Prenat Diagn.2011 Oct;31(10):973-7

Perinatal and Postnatal Management of CHD

Bhombal S, Kung G. Lost and Confused: An Unusual Case of Totally Anomalous Pulmonary Venous Connection. Congenital Cardiology Today, January 2014

Paquette L, Wisnowski JL, Del Castillo S, Pruetz JD, Detterich JA, Ceschin R, Nagasunder AC, Tavaré JC, Nelson MD, Seri I, Williams RG, Blüml S, and Panigrahy A. Microstructural Abnormalities in Central Visual Pathways in Neonates with Congenital Heart Disease. Am J Neuroradiol 2013 Oct;34:2026–33.

Trento L, Pruetz JD, Chang RK, Detterich J, Sklansky MS. Mode of Delivery and Early Outcomes in Infants with Congenital Heart Disease. Prenat Diagn. 2012 Dec;32(13):1250-5).

Portman MA, Slee A, Olson AK, Cohen G, Karl T, Tong E, Hastings L, Patel H, Reinhartz O, Mott AR, Mainwaring R, Linam J, Danzi S; Kung G (member of TRICC Investigators). Triiodothyronine Supplementation in Infants and Children Undergoing Cardiopulmonary Bypass (TRICC): a multicenter placebo-controlled randomized trial: age analysis. Circulation. 2010 Sep 14;122(11 Suppl):S224-33.

Kung GC, Chang PC*, Sklansky M, Randolph LA. Hypoplastic left heart syndrome in patients with Kabuki syndrome. Pediatr Cardiol. 2010 Jan;31(1):138-41

McLean M, Kung G, Polimenakos A, Reemtsen B, Starnes V, Wells W. Cor Triatriatum associated with ASD/common atrium in a seven month old with tachypnea and failure to thrive. Ann Thorac Surg. 2008 Dec;86(6):1999

Votava-Smith, JK, Perens GS, Alejos JC. Bosentan for increased pulmonary vascular resistance in a patient with single ventricle physiology and a bidirectional Glenn shunt. Pediatr Cardiol. 2007 Aug; 28(4): 314-316. Epub 2007 Jun 11.