Research Webinar Series: A synthetic lethality strategy in tumors with mitochondrial dysfunction

Webinar (Please email tecpad@chla.usc.edu if you wish to register)

Presented by Joanna Yeh, PhD
Assistant Professor
Harvard Medical School

Talk Summary: Metabolic reprogramming is an essential step toward tumorigenesis, suggesting that cancer-specific metabolic pathways could be targeted for therapeutic benefit. The majority of the presentation will focus on the identification of a candidate therapeutics against cancers exhibiting mitochondrial respiration deficiency as caused by oncogenic mutations, hypoxia, or chemical inhibition. In addition, data on CRISPR prime editing, a gene-editing platform for generating precise and user-defined mutations, in zebrafish and human primary T cells will also be discussed.

About the Speaker: Jing-Ruey Joanna Yeh, PhD is a biomedical researcher with strong interests in chemical biology and genome engineering technology development. Her current research focuses are directed towards (1) uncovering therapeutic approaches targeting cancer metabolism and (2) generating zebrafish genome engineering tools. Dr. Yeh received her PhD from Yale University working with Dr. Craig Crews on deciphering mechanisms of anti-angiogenic compounds. She then completed a postdoctoral fellowship with Dr. Randall Peterson at the Massachusetts General Hospital (MGH) working on in vivo chemical screening using zebrafish. She is presently an Assistant Professor at the Cardiovascular Research Center at MGH and Harvard Medical School.

Hosted by Ellen Lien, PhD
Investigator, Regenerative Medicine
Associate Professor of Surgery, Keck School of Medicine of USC

Brought to you by TSRI Office of Training, Education, Career Planning & Development (TECPAD)

Registration is required, email tecpad@chla.usc.edu to receive link