Research Seminar presented by Lisa Young, MD, Vanderbilt University School of Medicine

Speaker: Lisa Young, MD, Associate Professor of Pediatrics and Medicine, Vanderbilt University School of Medicine, Director of Research, Division of Pediatric Pulmonary Medicine, Director, Pediatric ILD/Rare Lung Diseases Clinic and LAM/Adult Rare Lung Diseases Clinic

Talk Summary: Hermansky-Pudlak Syndrome (HPS) is a family of autosomal recessive disorders characterized by oculocutaneous albinism and highly penetrant pulmonary fibrosis in young adults. HPS gene products are ubiquitously expressed, and recessive mutations result in defects in hetero-oligomeric protein trafficking complexes and abnormal lysosome-related organelle biogenesis. This presentation will provide data identifying mechanisms underlying alveolar epithelial cell dysfunction and evidence for how epithelial dysfunction is transduced to promote lung fibrosis in HPS. This presentation will also introduce ongoing efforts through the Rare Lung Diseases Consortium to establish clinical research centers for HPS in order to prepare for treatment trials.

About the Speaker: Dr. Lisa Young is an associate professor of Pediatrics, Medicine, and Cell and Developmental Biology and the Janie Robinson and John Moore Lee Chair in Pediatrics at Vanderbilt University. She received her undergraduate degree from The University of Virginia, followed by medical school and Medicine-Pediatrics residency at Duke University. After completing combined fellowship training in Pediatric and Adult Pulmonary Medicine in Cincinnati in 2005, she joined the faculty there. In 2011, Dr. Young moved to Vanderbilt, where she established Rare Lung Diseases clinics for children and adults, is the Director of the Center for Childhood Lung Research, and has a NIH-funded research program focused on pulmonary fibrosis and genetic causes of lung disease.

Hosted by Wei Shi, MD, PhD, Associate Professor of Surgery, Developmental Biology and Regenerative Medicine Program, The Saban Research Institute of Children’s Hospital Los Angeles, Department of Surgery, Keck School of Medicine, University of Southern California

RSVP is Required to tecpad@chla.usc.edu.