Research Seminar Series: Mechanisms and Therapeutic Implications of Liver Sinusoidal Endothelial Dysfunction in NASH
Seminar (Please email tecpad@chla.usc.edu if you wish to register)
Presented by Samar Ibrahim, MB, Ch.B
Associate Professor of Pediatric and Physiology, Mayo Clinic
Talk Summary: The talk will discuss novel mechanisms of lipotoxicity induced liver sinusoidal endothelial cell (LSEC) dysfunction, capillarization, and increased adhesion molecule expression. We will discuss preclinical studies using nonalcoholic steatohepatis mouse models and show that blocking the adhesion of immune cell to the sinusoidal endothelium attenuates liver, inflammation, injury, and fibrosis in NASH. We identify Vascular cell adhesion molecule-1 as a potential therapeutic target in NASH. We will also discuss the role of extracellular vesicles as a NASH catalyst in intercellular communication in the NASH liver microenvironment, and the potential role of their specific cargoes as disease biomarkers.
About the Speaker: Dr. Ibrahim is an Associate Professor of Pediatrics and Physiology, and the Medical Director of the Pediatric Liver transplant program at Mayo Clinic. She is the PI of the NIH-funded lipotoxicity and liver inflammation laboratory at Mayo Clinic. She studies the mechanism of liver injury and inflammation in NASH, with the goal to identify novel biomarkers and mechanism-based therapeutic targets. Dr. Ibrahim is an associate editor for “HEPATOLOGY” and a steering committee member of the AASLD pediatric special interest group. She is a NASPGHAN fellow, and a member of the NASPGHAN hepatology committee and the SPLIT education and advocacy committees.
Hosted By Rohit Kohli, MBBS, MS
Chief of the Division of Gastroenterology, Hepatology and Nutrition
Associates Chair in Liver and Intestinal Research
Attending Physician
Investigator, Gastroenterology, Hepatology and Nutrition
Professor of Pediatrics (Clinical Scholar), Keck School of Medicine of USC
Brought to you by TSRI Office of Training, Education, Career Planning & Development (TECPAD)
Registration is required, email tecpad@chla.usc.edu to receive link