Research Blog

Published on June 8, 2016
Screening of thousands of children in California suggests which mutations are disease-causing and which are benignWhen it comes to cystic fibrosis (CF), more than 2,000 different genetic mutations have been reported.  However, only 200 of them have been categorized – leaving a... Read More
Published on May 27, 2016
CHLA Physician Todd Chang is using serious gaming as a tool to train young doctors Activity in the emergency department (ED) in a pediatric hospital is fast-paced, and the most precious resource is time. With more than 80,000 patients to attend to every year for trauma, rare... Read More
Published on May 25, 2016
The California Institute for Regenerative Medicine awards grant to CHLA researcher for CRISPR/Cas9 project to treat genetic diabetesOften touted as one of the most revolutionary biomedical technologies of the modern age, the CRISPR/Cas9 gene editing system has already led to new... Read More
Published on May 19, 2016
Carotid artery thickness is fueled by androgen hormones in cases of classical adrenal hyperplasia according to a new research study out of Children’s Hospital Los Angeles. This finding has significant implications for preventing cardiovascular disease in young adults. Youth with... Read More
Published on May 17, 2016
From the Eat 5 a Day initiative to increase fruit and vegetable consumption to First Lady Michelle Obama’s Let’s Move campaign, many efforts have been made to curb the growing incidence of childhood obesity. But a troubling new study suggests a lot more work needs to be done.... Read More
Published on May 13, 2016
While human genome studies can lead to medical breakthroughs in the diagnosis and treatment of various conditions, the subject of genome research can also aggravate sensitivities. And while the knowledge that some health problems are more prevalent among certain populations has... Read More
Published on May 9, 2016
From skin rashes and hives to difficulty breathing and more serious reactions, food allergies affect up to six million children in the United States alone. But over the last two decades, researchers have discovered it can also lead to another condition known as eosinophilic... Read More
Published on May 5, 2016
“Natural killer" cell (green) attacks a leukemia cell (red). Courtesy of Eleanora Heisterkamp,PhD, Jihane Khalife, and Esteban Fernandez, PhD.Researchers at Children’s Hospital Los Angeles have shown that a select team of immune-system cells from leukemia patients can be... Read More
Published on May 3, 2016
Inadequate lung development can lead to a variety of pediatric disorders, especially in babies born prematurely. Understanding what drives proper lung development is important to developing new therapies for children with these disorders, but researching this can be complicated... Read More
Published on April 28, 2016
Evidence-based research proves they can with early educationA field trip to the local Ralph’s was a first for the Wiz Kids Preschool in Culver City, CA.  Thirty preschoolers between the ages of 3 and 5 were marched down Overland Avenue to shop for healthy food items from the... Read More
Published on April 25, 2016
In 2009, the Nobel Prize in Medicine was awarded for the discovery of telomerase, a previously little known protein that plays a key role in preventing damage to chromosomal DNA.“One of the recipients of the Nobel Prize, Dr. Elizabeth Blackburn, reminded us then that we are all... Read More
Published on April 21, 2016
Probiotics, bacteria believed to be beneficial for health, are thought to help with various gastrointestinal issues. A recent nationwide study published in the American Journal of Infection Control found it is common for hospitals to prescribe probiotics to patients with a... Read More
Published on April 19, 2016
Cultured retinoblastoma tumor containing tumor cells (red) and fibroblasts (green).  Researchers at The Saban Research Institute of Children’s Hospital Los Angeles (CHLA) have demonstrated that targeting survivin – a protein that inhibits apoptosis or cell death –... Read More
Published on April 13, 2016
A staple of pediatric  healthcare, antibiotics are the most prescribed medication for children. However, the long-term effects of these medications remain relatively unknown. Last month, two studies looked into the links between antibiotic use and childhood obesity, finding... Read More
Published on April 8, 2016
Shedding epithelial cells in the intestine. Image courtesy of Mark R. Frey, PhD, The Saban Research Institute, Children’s Hospital Los Angeles.The lining of the intestine is the most rapidly-renewing tissue in the body. Routine shedding of epithelial cells from this lining is a... Read More
Published on April 6, 2016
Children’s Hospital Los Angeles to Initiate Clinical Trial for Kids with Treatment-Resistant LeukemiaResearchers at Children’s Hospital Los Angeles will be testing a new therapy for acute lymphoblastic leukemia using specially engineered T-cells isolated from patients that can... Read More
Published on April 4, 2016
In a new editorial published in JAMA Pediatrics, Johanna Olson-Kennedy, MD, medical director of The Center for Transyouth Health and Development at Children’s Hospital Los Angeles discusses disparities in mental health in young transgender populations. A recent study, also... Read More
Published on March 31, 2016
Here we see the development of the brain-pancreas axis during gestation. According to a new study out of Children’s Hospital Los Angeles, the hormone leptin alters neuronal growth between the brain and pancreas during embryonic development, which may play a role in the onset... Read More
Published on March 29, 2016
Eczema or atopic dermatitis is a condition where the areas of the skin are inflamed, resulting in symptoms ranging from redness to severe rashes and blisters. The specific causes of eczema remain unknown, though the condition has been linked to other conditions ranging from... Read More
Published on March 24, 2016
Children’s Hospital Los Angeles Awarded $7.1 Million by CIRM to develop new cellular therapy to treat digestive nerve disordersHirschsprung’s disease, where crucial nerve cells are absent in parts of the gastrointestinal tract resulting in the inability to properly push food... Read More