Research Blog

Published on January 30, 2017
156588189347_0.jpg
Investigators at Children’s Hospital Los Angeles, led by Tracy C. Grikscheit, MD, have mapped the genetic changes resulting from short bowel syndrome (SBS) using a novel zebrafish model and by performing intensive gene sequencing. This approach to determining which genes are... Read More
Published on January 9, 2017
155634503822_0.jpg
Characterized by repetition of sounds, syllables, or words; prolongation of sounds; and interruptions in speech, stuttering occurs most often in children between the ages of 2 and 6 as they are developing their language skills. While 75 percent outgrow or recover from stuttering... Read More
Published on January 3, 2017
155354689992_0.jpg
Innate immune cells of the myeloid lineage (primarily macrophages and neutrophils) surrounding the epithelial crypts in inflamed colonic tissue. Inflammatory Bowel Disease (IBD) is a debilitating, incurable condition affecting approximately 1.5 million... Read More
Published on December 13, 2016
154429856192_0.jpg
Doctors in training, known as medical residents, often find themselves tasked with significant clinical responsibilities while continuing to learn how to be a physician. Many hospitals offer lecture conferences to supplement the education of residents, but turnout to these... Read More
Published on December 6, 2016
154135940097_0.jpg
Investigators from Children’s Hospital Los Angeles and 37 other Children’s Oncology Group hospitals in the U.S. and Canada have determined that sodium thiosulfate prevents cisplatin-induced hearing loss in children and adolescents with cancer. Results of this randomized,... Read More
Published on November 29, 2016
153833816027_0.jpg
Differences in Neural Density between Stuttering and Control Participants Blue: reduced neural density in stutterers; Red: increased neural density in stutterersResearchers at Children’s Hospital Los Angeles (CHLA) have conducted the first study of its kind, using proton... Read More
Published on November 17, 2016
153319027807_0.jpg
Human Native Lung (left) and Tissue Engineered Lung (right)Scientists at Children’s Hospital Los Angeles have developed a tissue-engineered model of lung and trachea which contains the diverse cell types present in the human respiratory tract.  The study, led by principal... Read More
Published on November 4, 2016
152734159347_0.jpg
Children with sleep apnea may be at increased risk for overnight respiratory events (ORE) following anesthesia.  But researchers at Children’s Hospital Los Angeles (CHLA) wondered if the practice of hospitalizing a child overnight following sedation for certain non-surgical... Read More
Published on October 27, 2016
152396607647_0.gif
A study by researchers from The Saban Research Institute of Children’s Hospital Los Angeles reveals a promising therapeutic target for improving lung function in infants. Their study, now published online by the American Journal of Physiology-Lung Cellular and Molecular... Read More
Published on October 17, 2016
151947509102_0.jpg
Microscopic image: MDM2 expression (in red) in retinoblastoma Rb176 cells. Credit: Donglai Qi, PhD, and David Cobrinik, MD, PhD. Researchers at The Saban Research Institute of Children’s Hospital Los Angeles have identified an unsuspected and critical role... Read More
Published on October 12, 2016
151712781032_0.jpg
Recently, Yoshinori Ohsumi was awarded the 2016 Nobel Prize in Physiology or Medicine for his discoveries of mechanisms for a fundamental process called autophagy. Mutations in autophagy genes can cause disease, and disturbances in the autophagic process can lead to diabetes,... Read More
Published on September 30, 2016
151164595327_0.jpg
The Food and Drug Administration has approved the first drug to treat patients with Duchenne muscular dystrophy, the most common muscular dystrophy diagnosed in childhood. Some experts contend that not enough evidence exists to prove the drug – eteplirsen – is effective, because... Read More
Published on September 28, 2016
151066738222_0.jpg
Join Rita Burke, PhD, MPH. on a Twitter chat about disaster preparedness for families | September 29 between 1 – 2 PM EST at www.PHE.gov/Prep2Grow | Sponsored by the U. S. Office of the Assistant Secretary of Preparedness and Response Hurricane Katrina was a wakeup call to... Read More
Published on September 23, 2016
150827093077_0.jpg
Military personnel can be exposed to dusts and toxicants in the field that may contribute to lung disease. The available technologies to detect early-stage alterations of lung function in patients require a long processing time and lack satisfactory sensitivity and resolution,... Read More
Published on September 16, 2016
150511135322_0.jpg
Recent studies have indicated an increased need for preventive mental health and social services among Filipinos, in part because of higher rates of problem behaviors such as substance use, high school dropout, and teen births compared to other Asian subgroups. Filipino... Read More
Published on September 14, 2016
150405989342_0.jpg
In a first-of-its-kind look at human kidney development, researchers at The Saban Research Institute of Children’s Hospital Los Angeles have isolated human nephron progenitor (NP) cells.  Their results, published online in the journal Stem Cell Translational Medicine, will help... Read More
Published on September 9, 2016
150176772772_0.jpg
Surface of the mouse colon repaired by stem cells after a flare of ulcerative colitis. The different colors show the contributions of individual stem cells as they have multiplied to patch the breaks, or ulcers, in the colonic surface. These ulcers were originally caused by the... Read More
Published on September 6, 2016
150036059912_0.jpg
Genetic Intersection of Conditions AnalyzedResearchers at the Institute for the Developing Mind at Children’s Hospital Los Angeles have analyzed current gene-disease findings to understand why people with neurodevelopmental and mental illness often have physical disorders.Their... Read More
Published on September 2, 2016
149846697252_0.jpg
Concussions are a form of mild traumatic brain injury resulting in transient functional and biochemical changes in the brain. According to a study conducted by researchers at the University of California, San Francisco, the rates of concussions are purportedly on the rise among... Read More
Published on August 30, 2016
149717918742_0.jpg
biodegradable scaffold (left) and human tissue-engineered liver (right)A research team led by investigators at The Saban Research Institute of Children’s Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells.... Read More

Pages