Research Blog

Published on October 2, 2020
Google Accelerated Sciences is a translational research team that works to bring Google’s technology to the biomedical community. Philip Nelson, Director of Engineering at Google Accelerated Sciences, will meet with team members at Children’s Hospital Los Angeles on Wednesday,... Read More
Published on September 17, 2020
One of the mysteries about SARS-CoV-2, the virus that causes COVID-19, is how it is spread within households, including why some family members develop the viral infection and others do not. Is there a way to predict who will be symptomatic or asymptomatic and how long... Read More
Published on September 8, 2020
A study by investigators at Children’s Hospital Los Angeles found that patients who lost weight in the first year following diagnosis were better able to control blood glucose levels, decreasing their risk of serious complications. Read More
Published on August 12, 2020
Acute lymphoblastic leukemia (ALL) affects about 3,000 children each year in the United States. In one tenth of cases, the cancer resists treatment. Yong-Mi Kim, MD, PhD, MPH investigates just how cancer cells evade chemotherapy. Her newest study, featured on the cover of the... Read More
Published on August 6, 2020
Mark Frey, PhD, an investigator at The Saban Research Institute of Children’s Hospital Los Angeles, studies how the intestines repair themselves after injury. Read More
Published on July 7, 2020
In a study published in The American Journal of Clinical Nutrition, Dr. Goran and his colleagues show that sugar intake during the first 6 months postpartum is associated with weight gain.  Read More
Published on June 29, 2020
Placement of an intravenous catheter—to allow health care providers the ability to easily take blood or administer medications—is one of the most common inpatient procedures. Although necessary for care and patient comfort, the devices may also be associated with infection,... Read More
Published on June 17, 2020
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A new study published in JAMA Pediatrics shows, for the first time, that brain anatomy and metabolism are affected by prenatal drug exposure and that these brain changes underlie neurodevelopmental outcomes one year later. Read More
Published on June 3, 2020
In the face of the COVID-19 pandemic, changes must be made to how patients are resuscitated. Normal procedures such as intubation and CPR can allow viruses to spread.  The American Heart Association has provided changes to prior guidelines to reduce or eliminate the amount of... Read More
Published on June 2, 2020
Patients of different ages and ethnicities, from a range of geographic locations, have been exhibiting varying types of illness and symptom severity due to COVID-19. While children were initially thought to be less affected by the disease than adults, they can recover from... Read More
Published on June 1, 2020
COVID-19 has required changes in every level of patient care as the nation strives to maintain safe intrapersonal distance. One way Children’s Hospital Los Angeles has addressed this issue is through the development and use of chatbots—software applications that mimic spoken... Read More
Published on May 31, 2020
In the most severe cases of COVID-19, patients suffer from acute respiratory distress syndrome (ARDS), which can be fatal. Ventilator management in ARDS is complicated, and randomized trials have demonstrated that failure to provide good lung-protective ventilation results in... Read More
Published on May 30, 2020
Early reports suggested that hydroxychloroquine (HCQ), a drug used to prevent malaria and treat children with certain rheumatologic conditions like lupus, may relieve inflammation associated with moderate or severe COVID-19. Michael Neely, MD, MSc, was lead investigator on a... Read More
Published on May 29, 2020
To fight a disease that is affecting the entire world, the disease must be better understood. Scientists and clinicians need data about the disease spectrum, optimal sample types for testing, and duration of virus shedding. Unfortunately, this type of information is quite... Read More
Published on May 28, 2020
COVID-19 is caused by the novel coronavirus, SARS-CoV-2, infecting the respiratory system. Specifically, the spike protein (S1 subunit) of the virus binds to a protein receptor called angiotensin converting enzyme 2 (ACE2) on lung epithelial cells. This interaction is a key step... Read More
Published on May 27, 2020
Since the onset of the COVID-19 pandemic, scientists and clinicians have sought to better understand the virus and how it spreads. Analysis of antibodies developed against the coronavirus can offer insight into timing and extent of illness. Read More
Published on May 26, 2020
The COVID-19 pandemic is a major stressor in the lives of the global community, but perhaps greatest for adolescents and young adults, who don’t always have resources to help them cope. To assess psychosocial stress and coping in adolescents, Ji-Ting Janet Yau, DO, has developed... Read More
Published on May 22, 2020
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Children’s Hospital Los Angeles surgeon Tracy Grikscheit, MD, achieves milestone in preclinical research for Hirschsprung’s Disease  Read More
Published on May 1, 2020
Adolescence is a time of great change, both emotionally, socially and physically. To understand how these changes affect the health of our nation’s children as they develop, the National Institutes of Health (NIH) has funded the Adolescent Brain Cognitive Development – or ABCD... Read More
Published on March 31, 2020
CHLA scientists work toward a new therapy to target resistant leukemia. Their study, recently published in the journal Leukemia, shows that these new CAR-T cells could be the answer to resistant leukemia. Read More