Research Blog

Published on September 10, 2014
During the month of August, two publications delved into the decades-old debate questioning exactly how drastically a mother’s activities while pregnant affect her child in the future—specifically in terms of alcohol consumption. We asked Elizabeth Sowell, PhD, director of the... Read More
Published on September 9, 2014
We know that “breast is best” when it comes to passing essential nutrients like hormones, antiviral factors and enzymes from mother to baby. But researchers recently discovered that a growth factor found in breast milk–and absent from formula–may be... Read More
Published on September 5, 2014
The current drought makes California look like fat cells under a microscope! Dried-out land on the left, adipocytes (fat cells) on the right. Image courtesy of Sebastien Bouret, PhD, from The Saban Research Institute.  Read More
Published on September 2, 2014
Scientists have linked literally hundreds of mutated genes with autism spectrum disorder (ASD), a success rate that could be viewed as both an important first step toward future interventions and an increasingly complex puzzle.Di Tian, MD, PhD, an investigator in the... Read More
Published on August 29, 2014
Like an archipelago in the Pacific, one million isolated clusters of cells pepper the pancreas. Called the Islets of Langerhans, these regions contain a large portion of the body’s endocrine (hormone-producing) cells—including those that regulate diabetes. In this image, the... Read More
Published on August 28, 2014
Kids from Camp H.E.A.L. do! An acronym for “Healthy Environment, Active Living,” Camp H.E.A.L is the newest community-outreach initiative of Children’s Hospital Los Angeles’ Diabetes and Obesity Program and New Mount Calvary Missionary Baptist Church. Through... Read More
Published on August 25, 2014
-Pat Levitt, PhD, Simms/Mann Chair in Developmental Neurogenetics at Children’s Hospital Los Angeles. Read about how Dr. Levitt is untangling our brain’s wiring to understand neurodevelopmental disorders in “How We Become What We Become” Read More
Published on August 22, 2014
Explaining the role of ErbB4 regulators in inflammatory bowel disease (IBD), Patricia Lozano exudes poise and confidence. In front of fellow interns, she reviews the causes of IBD and discusses how understanding the effect of pro-inflammatory cytokines on ErbB4 in intestinal... Read More
Published on August 19, 2014
(No, it’s not the sun.) Leukemia cell coated with antibody is marked for destruction by activated natural killer cells. Researchers at Children’s Hospital Los Angeles have shown that a select team of immune-system cells from patients with leukemia can be multiplied in the... Read More
Published on August 18, 2014
Red fibers show growing axons—the part of the nerve cell that sends out signalsSeveral studies have shown that maternal obesity is associated with increased risks for obesity, hypertension and type 2 diabetes in the offspring. There is also growing appreciation that the... Read More
Published on August 15, 2014
Like most doctors, Thomas Coates, MD, tells his patients not to worry. Yet, unlike the gentle encouragement typically offered by clinicians, Coates’ advice is prescriptive.As a pediatric hematologist who treats one of the largest populations of patients with sickle cell disease... Read More
Published on August 13, 2014
Normal microscopic anatomy of the large intestine  Bloating, gas, abdominal pain and diarrhea are physically uncomfortable and often taboo topics, but for children with gastrointestinal (GI) disorders, these symptoms dictate day-to-day life. With two clinical trials exploring... Read More
Published on August 11, 2014
David Vetter, publically known as the “bubble boy”. Image courtesy of Science Source. With a physical exam and quick prick of the heel, doctors can detect dozens of serious medical conditions immediately after birth. Severe combined immune deficiency (SCID) is one... Read More
Published on August 6, 2014
Technological innovations in health care can save lives and increase quality of life. Pacemakers restore rhythm to the heart, stents prop open weak arteries, and artificial knees and hips bring patients back to their feet.But these devices aren’t meant for children.“For years... Read More
Published on August 4, 2014
In the first longitudinal study of its kind, Prapti Gautam, PhD, and colleagues from The Saban Research Institute of Children’s Hospital Los Angeles found that children with fetal alcohol spectrum disorders (FASD) showed weaker brain activation during specific cognitive tasks... Read More
Published on July 23, 2014
Reaching temperatures as low as -40 degrees Fahrenheit (an incomprehensible number, especially to Angelenos), Ulaanbaatar, Mongolia is the coldest capital city in the world. And it’s also one of the most polluted. In this rapidly-developing city, particulate air pollution... Read More
Published on July 18, 2014
Normal vs. osteoporotic bone. Image source: WebMD When children and adolescents go in for their yearly check-ups, the term “osteoporosis” is rarely mentioned. But it turns out that signs of this adult disease can be seen in kids decades before symptoms appear.Generally... Read More
Published on July 11, 2014
After nearly a decade in post-secondary education, a select few continue on and commit to specialized research training after earning their PhD. These postdoctoral scholars, commonly referred to as “postdocs", are training to become the leading researchers in their fields... Read More
Published on July 9, 2014
Photo by Anat Erdreich-Epstein, MD, PhD, from The Saban Research Institute of Children’s Hospital Los Angeles  In December 2013, Anat Erdreich-Epstein, MD, PhD, and colleagues were the first to link the level of RNA in the PID1 protein to brain tumor growth. Erdreich-... Read More
Published on July 3, 2014
Controlling our thoughts, actions and even our thoughts about our actions, the brain is an incredible powerhouse that shapes us into who we are. But its appearance and functions change as we grow up, making it important that researchers observe the brain during every stage of... Read More