Research Blog

Published on March 17, 2015
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While it’s no decades-old tradition like dyeing the Chicago River, fluorescent green dye plays a crucial role in medical research by marking microscopic structures like neurons and stem cells. In honor of St. Patty’s Day, here are a few of our favorite images that will have you... Read More
Published on March 12, 2015
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As the “bouncers” of blood composition, our kidneys are responsible for making sure crucial nutrients and electrolytes circulate through our body and that waste is filtered out. Unfortunately, when podocytes—the key cells in charge of filtration—deteriorate, renal function is... Read More
Published on March 4, 2015
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With an average of 26 years of our lives spent in a drooling, dreaming slumber, it’s no wonder we dedicate almost as much time to understanding those crucial Zzz’s. Because of this interest, research in sleep medicine—especially in pediatric sleep medicine—has made crucial... Read More
Published on March 2, 2015
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Dehydration, abdominal pain and diarrhea are all common symptoms of colitis—a disease caused by inflammation of the large intestine’s lining. But most people don’t know that, in addition to these uncomfortable gastrointestinal issues, colitis can also lead to an increased risk... Read More
Published on February 26, 2015
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“Bays of Our Lives” is a series that goes behind the laboratory bench (also called a “bay”) to highlight the individual personalities behind innovative research at Children’s Hospital Los Angeles (CHLA). I recently caught up with Philip Dubé, PhD, a gastroenterology researcher... Read More
Published on February 20, 2015
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PTSD. Four letters we immediately associate with soldiers and horrific wartime tragedies. But unfortunately, posttraumatic stress disorder (PTSD) can affect anyone who has experienced a traumatic event—including children with serious medical diagnoses. Called medical PTSD, this... Read More
Published on February 16, 2015
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From regulating our metabolism and mood to influencing overall growth and development, hormones intimately govern how our body works—especially during childhood and adolescence. But for youth with human immunodeficiency virus (HIV), infections and HIV-fighting antiretroviral... Read More
Published on February 9, 2015
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Deep within the brain’s hypothalamus, there is a collection of neurons that serve as the central regulators of appetite, metabolism and fat storage. Called the arcuate nucleus, these neurons respond to circulating hunger and satiety signals in blood, increasing or decreasing our... Read More
Published on February 5, 2015
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Did you know that children who are obese when they’re diagnosed with leukemia are more likely to relapse after chemotherapy? In fact, there’s a 50% higher chance that the cancer will return in these patients when compared to their lean counterparts.Researchers from ... Read More
Published on February 2, 2015
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As you can see above, crescent-shaped red blood cells have a hard time making their way through the blood vessels of individuals with sickle cell disease (SCD). These roadblocks in cellular travel can cause serious pain, prevent oxygen and nutrients from reaching tissues and... Read More
Published on January 28, 2015
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Three-dimensional printing technology can make surgery safer for children with congenital heart disease and reduce the duration, as well as the number of invasive procedures, required. Richard Kim, MD, a cardiac surgeon at Children’s Hospital Los Angeles (CHLA), recently used a... Read More
Published on January 26, 2015
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Accounting for about one quarter of all childhood cancer diagnoses, acute lymphoblastic leukemia (ALL) is one of the most common malignancies affecting kids under the age of 15. In the past, ALL had a high mortality rate; nearly 80 percent of the children with the disease did... Read More
Published on January 20, 2015
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Our motivation to eat can be influenced by any number of sources—a friend’s decadent Instagram post, a new restaurant review that has you drooling, or simply the urge stave off boredom on a Wednesday night. But despite all of these external cues, our biological motivation to... Read More
Published on January 13, 2015
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Researchers at Children’s Hospital Los Angeles (CHLA) have grown functional tissue-engineered intestine from human cells. This regenerative medicine technique brings surgeons one step closer to helping patients with devastating intestinal disorders like short bowel syndrome... Read More
Published on January 8, 2015
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Did you guess that the images above depict optic nerve hypoplasia (ONH)? ONH is a congenital condition that occurs when the optic nerve–which sends signals from the eye to the brain–is underdeveloped. In his lab at The Saban Research Institute, Mark Borchert, MD,... Read More
Published on January 2, 2015
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Found in soil and plants throughout the world, Cryptococcus neoformans (C. neoformans) is a common, harmless fungus that we encounter every day. But for people with a weakened immune system, these exposures can be deadly. Above, you can see parts of the C. neoformans plasma... Read More
Published on December 29, 2014
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We all know the phrase “sticks and stones may break my bones, but words will never hurt me.” Unfortunately, this may not be true. Yaling Yang, PhD, from The Saban Research Institute at Children’s Hospital Los Angeles, recently discovered that the harsh words of school-age... Read More
Published on December 24, 2014
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From developing a new genetic sequencing test for retinoblastoma to determining the long-term effects of fetal alcohol spectrum disorders, researchers at Children’s Hospital Los Angeles (CHLA) made key strides in 2014.   Based on media and website engagement, and in... Read More
Published on December 22, 2014
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Image Caption: MR Spectroscopy is generally used to measure concentrations of chemicals in tissue. However, it can also be used to determine the temperature of the tissue by measuring the position of the water signal relative to other chemicals. The water peak moves away from... Read More
Published on December 18, 2014
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That’s gotta hurt!  Occurring right above the elbow joint, supracondylar humerus fractures (as shown above) are a common pediatric injury and account for over half of elbow fractures in kids. But what’s the best way to set and cast these fractures? Researchers from... Read More

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