Research Blog

Published on April 9, 2015
Pointillism artwork can be seen on museum walls and under the microscope. Left: Stem cells stained with DAPI blue, The Saban Research Institute of Children’s Hospital Los AngelesRight: Study for “The Channel at Gravelines, Evening,” Georges Seurat (1890). Musée de l'Annonciade,... Read More
Published on April 7, 2015
Since 2000, the rate of infants born with an addiction to narcotics or other drugs has tripled in the U.S. Dr. Friedlich and Claire McLean, MD, address this growing issue on First 5 LA:“If substances of abuse exist, pregnant women will use them just like anyone else and my... Read More
Published on April 2, 2015
In a condition as heterogeneous as autism spectrum disorder(ASD), finding a shared root of behavioral and neurological symptoms is often a shot in the dark. But in the mid-2000s, researchers found a genetic mutation in one percent of children with ASD, making it the most common... Read More
Published on March 31, 2015
In the fall of last year, a severe respiratory illness crept across the country, causing a string of infections in children. While most of those affected—even those that were hospitalized—recovered fully, a handful of kids with the enterovirusD68 (EV-D68) infection experienced... Read More
Published on March 30, 2015
Characterizing associations between socioeconomic factors and children’s brain development, a team of investigators from nine universities across the country reports correlative links between family income and brain structure. Relationships between the brain and family income... Read More
Published on March 27, 2015
Caption: Comparative sizes of fetal and adult pacemakers. Credit: Children’s Hospital Los AngelesA team of investigators at Children’s Hospital Los Angeles and the University of Southern California have developed the first fully implantable micropacemaker designed for use in a... Read More
Published on March 25, 2015
Prenatal Exposure to Common Air Pollutants Linked to Cognitive and Behavioral ImpairmentEveryday pollutants in and outside the home can be bad for the environment…and bad for your baby’s brainResearchers at the Institute for the Developing Mind at Children’s Hospital Los Angeles... Read More
Published on March 18, 2015
Caption: Transgenic mouse model used to target lung mesenchymal cells (green). Credit: Wei Shi, MD, PhD, Developmental Biology and Regenerative Medicine Research Program at Children’s Hospital Los Angeles___________________________________________________By uncovering the... Read More
Published on March 17, 2015
While it’s no decades-old tradition like dyeing the Chicago River, fluorescent green dye plays a crucial role in medical research by marking microscopic structures like neurons and stem cells. In honor of St. Patty’s Day, here are a few of our favorite images that will have you... Read More
Published on March 12, 2015
As the “bouncers” of blood composition, our kidneys are responsible for making sure crucial nutrients and electrolytes circulate through our body and that waste is filtered out. Unfortunately, when podocytes—the key cells in charge of filtration—deteriorate, renal function is... Read More
Published on March 4, 2015
With an average of 26 years of our lives spent in a drooling, dreaming slumber, it’s no wonder we dedicate almost as much time to understanding those crucial Zzz’s. Because of this interest, research in sleep medicine—especially in pediatric sleep medicine—has made crucial... Read More
Published on March 2, 2015
Dehydration, abdominal pain and diarrhea are all common symptoms of colitis—a disease caused by inflammation of the large intestine’s lining. But most people don’t know that, in addition to these uncomfortable gastrointestinal issues, colitis can also lead to an increased risk... Read More
Published on February 26, 2015
“Bays of Our Lives” is a series that goes behind the laboratory bench (also called a “bay”) to highlight the individual personalities behind innovative research at Children’s Hospital Los Angeles (CHLA). I recently caught up with Philip Dubé, PhD, a gastroenterology researcher... Read More
Published on February 20, 2015
PTSD. Four letters we immediately associate with soldiers and horrific wartime tragedies. But unfortunately, posttraumatic stress disorder (PTSD) can affect anyone who has experienced a traumatic event—including children with serious medical diagnoses. Called medical PTSD, this... Read More
Published on February 16, 2015
From regulating our metabolism and mood to influencing overall growth and development, hormones intimately govern how our body works—especially during childhood and adolescence. But for youth with human immunodeficiency virus (HIV), infections and HIV-fighting antiretroviral... Read More
Published on February 9, 2015
Deep within the brain’s hypothalamus, there is a collection of neurons that serve as the central regulators of appetite, metabolism and fat storage. Called the arcuate nucleus, these neurons respond to circulating hunger and satiety signals in blood, increasing or decreasing our... Read More
Published on February 5, 2015
Did you know that children who are obese when they’re diagnosed with leukemia are more likely to relapse after chemotherapy? In fact, there’s a 50% higher chance that the cancer will return in these patients when compared to their lean counterparts.Researchers from ... Read More
Published on February 2, 2015
As you can see above, crescent-shaped red blood cells have a hard time making their way through the blood vessels of individuals with sickle cell disease (SCD). These roadblocks in cellular travel can cause serious pain, prevent oxygen and nutrients from reaching tissues and... Read More
Published on January 28, 2015
Three-dimensional printing technology can make surgery safer for children with congenital heart disease and reduce the duration, as well as the number of invasive procedures, required. Richard Kim, MD, a cardiac surgeon at Children’s Hospital Los Angeles (CHLA), recently used a... Read More
Published on January 26, 2015
Accounting for about one quarter of all childhood cancer diagnoses, acute lymphoblastic leukemia (ALL) is one of the most common malignancies affecting kids under the age of 15. In the past, ALL had a high mortality rate; nearly 80 percent of the children with the disease did... Read More