Research Blog

Published on February 16, 2016
Normal lung (image A) compared to lung developed with low levels of VEGF (image B) demonstrating abnormal air spaces and lung tissue. Photo courtesy of Grikscheit Lab, The Saban Research Institute of Children’s Hospital Los AngelesInvestigators at The Saban Research Institute of... Read More
Published on February 14, 2016
Here we see proliferating cardiomyocytes or heart cells from zebrafish. Zebrafish, a tropical fish in the minnow family commonly used in scientific research, is known best for its regenerative abilities. Researchers at Children’s Hospital Los Angeles led by Ching-Ling Lien, PhD... Read More
Published on February 12, 2016
Patients with acute lymphoblastic leukemia are at increased risk for bone fractures due to bone loss resulting from treatment. This decrease in bone density (as illustrated here) can occur as soon as the first month of treatment according to new research out of Children’s... Read More
Published on February 10, 2016
Stickers proclaiming “BPA-free” status are increasingly common on plastic bottles. BPA or Bisphenol A was used at one point to increase the strength of plastic, though was phased out when studies demonstrated the chemical had several significant negative health. Since then, BPS... Read More
Published on February 8, 2016
Leukemia cells (yellow) shown dispersed among fat cells (red) surrounded by supportive cells (blue). Image courtesy of Steven Mittelman, MD, PhD, Children’s Hospital Los Angeles.An interdisciplinary research team at The Saban Research Institute of Children’s Hospital Los Angeles... Read More
Published on February 5, 2016
Throughout football season and leading up to the Super Bowl, an increase in ACL injuries is inevitable. Image courtesy of Shutterstock.A common and often devastating injury in sports – anterior cruciate ligament (ACL) injury can require surgery to restore knee stability and... Read More
Published on February 3, 2016
Neuroblastoma cells under a microscope labeled with fluorescent molecules. Image courtesy of Shutterstock.Building upon more than two decades of basic research conducted at Children’s Hospital Los Angeles, Araz Marachelian, MD, of CHLA, and her colleagues at pediatric academic... Read More
Published on February 2, 2016
Food allergy or intolerance can cause symptoms ranging from a harmless skin rash to a potentially lethal anaphylactic shock. An estimated 15 million Americans suffer from food allergies, many of them children.The prevalence of food allergy is higher among children and is... Read More
Published on January 28, 2016
Exposure to anesthesia during labor and delivery results in morphological changes in the developing fetal brain. Photo credit: Bradley Peterson, MD, Institute of the Developing Mind, Children’s Hospital Los Angeles.Recently recommended in F1000Prime, which identifies significant... Read More
Published on January 26, 2016
A recent study demonstrated a link between bariatric surgery and improved mental health outcome, specifically reduced depression among patients after bariatric surgery. To learn more about the relationship between mental health and obesity in children, we spoke to Mari Radzik,... Read More
Published on January 21, 2016
A genetic variation, or the “s” allele, was associated with thicker cortex in the high risk (top row) but with thinner cortex in the low risk (bottom row) individuals. Image courtesy of Ravi Bansal, PhD, Children’s Hospital Los Angeles.Building on a 30-year, three-generation... Read More
Published on January 20, 2016
In a new article published in Trends in Cognitive Sciences, corresponding author Elizabeth Sowell, PhD of Children’s Hospital Los Angeles, in collaboration with authors from Harvard Medical School and San Diego State University, reviewed ongoing research efforts to determine... Read More
Published on December 28, 2015
Bubbles ‘n BowelsSmall bowel syndrome (SBS), a disorder characterized by malabsorption of nutrients due to removal of parts of the small intestine, affects roughly 9000 children and 3500 adults in the United States annually. Surgical removal of the intestine is often done in... Read More
Published on December 24, 2015
Either way, we hope your holidays are stimulating!from The Saban Research Institute of Children’s Hospital Los Angeles Read More
Published on December 20, 2015
Sex-based differences in incidence and long-term outcomes have been well documented in pediatric cancer patients. Investigators at Children’s Hospital Los Angeles have now discovered similar differences in acute side effects due to treatment in pediatric patients with acute... Read More
Published on December 11, 2015
Purple haze, all in my lungA variety of signaling molecules control the branching program by which the lung grows and develops. In this image we see the beginning of normal branching that occurs at budding points of the lung known as epithelial tips. Researchers at Children’s... Read More
Published on December 4, 2015
Newborn brain images show total maternal prenatal iron intake (purple) correlates with tissue organization and development. Image courtesy of Bradley Peterson, MD, The Saban Research Institute, Children’s Hospital Los Angeles.In the first study of its kind, researchers have... Read More
Published on December 2, 2015
Dr. Joe Church, shown with patient Cristina Jade Peña in 1994.  Today, at age 31, Cristina is leading “a wonderful and happy life, because of medical advancements, and the lifesaving care and treatment by Dr. Church and his team at CHLA.”Joseph Church, MD, has a thick stack of... Read More
Published on December 1, 2015
Individuals with autism spectrum disorder (ASD) often have difficulty recognizing and interpreting how facial expressions convey various emotions – from joy to puzzlement, sadness to anger.  This can make it difficult for an individual with ASD to successfully navigate social... Read More
Published on November 19, 2015
Birth of a NeuronWhat can the developing brain, specifically the birth of neurons (green), tell us about predisposition to childhood obesity and diabetes? Researchers at Children’s Hospital Los Angeles, led by Sebastien Bouret, PhD, are investigating how neuron development in... Read More