Research Blog

Published on March 22, 2016
A new study out of Children’s Hospital Los Angeles has found excessive fat in legs of children with a severe form of spina bifida suggests increased risk for metabolic disordersRepresentative quantified computed tomography (CT) slices showing excess adipose or fatty tissues (... Read More
Published on March 18, 2016
Despite Increases in Screening, Study Finds Only 44 Percent of Pediatricians Inquire about Maternal DepressionMaternal depression affects up to 40 percent of mothers with young children and can have many negative effects on the infant and developing child including feeding... Read More
Published on March 14, 2016
Study suggests macrophage activation as possible reason for differential bone loss in adolescent malesActivation of macrophages – a type of immune cell which, in the bone, takes the form of bone-eating osteoclast cells (above) – may play a significant role in bone loss found in... Read More
Published on March 10, 2016
Research suggests racism experienced in childhood can lead to health problems later in life.While overall health has improved, from reduced infant mortality to improved outcomes for a variety of diseases, racial and ethnic disparities in health remain a significant problem that... Read More
Published on March 2, 2016
Comparison of radiation exposure in x-ray based photon radiotherapy (left) and proton radiotherapy (right). Image source: Taheri-Kadkhoda et al. Radiation Oncology 2008 3:4 doi:10.1186/1748-717X-3-4, Creative Commons Attribution 2.0 Generic. Medulloblastoma, the most common... Read More
Published on February 29, 2016
Robert Seeger, MD, division head for Basic and Translational Research of the Center for Cancer and Blood Diseases at Children’s Hospital Los Angeles (CHLA) has been selected for the 2016 Lifetime Achievement Award from the Pediatric Blood and Marrow Transplant Consortium (PBMC... Read More
Published on February 27, 2016
The Flint, Michigan water crisis raises concerns about the effects of lead poisoning on children. According to the World Health Organization, lead poisoning accounts for 0.6% of the global burden of disease. Children are particularly susceptible to the effects of lead poisoning... Read More
Published on February 24, 2016
In 2006, researchers studying obesity stumbled upon a gene called PID1 (Phosphotyrosine Interaction Domain containing 1). They found the gene played a role in insulin resistance in obese patients, making it a target for development of new treatments for obesity.Three years after... Read More
Published on February 21, 2016
A once relatively unknown virus has recently made headlines as over 4000 cases of severe birth defects connected to the virus have been reported in Brazil. The Zika virus is related to the dengue and west Nile viruses and has many researchers scrambling to uncover both how the... Read More
Published on February 18, 2016
Children’s Hospital Los Angeles (CHLA) and Thermo Fisher Scientific have agreed to develop a next-generation sequencing (NGS)-based panel designed specifically for pediatric cancer research.  The assay would be CHLA’s first NGS panel designed to target biomarkers associated with... Read More
Published on February 16, 2016
Normal lung (image A) compared to lung developed with low levels of VEGF (image B) demonstrating abnormal air spaces and lung tissue. Photo courtesy of Grikscheit Lab, The Saban Research Institute of Children’s Hospital Los AngelesInvestigators at The Saban Research Institute of... Read More
Published on February 14, 2016
Here we see proliferating cardiomyocytes or heart cells from zebrafish. Zebrafish, a tropical fish in the minnow family commonly used in scientific research, is known best for its regenerative abilities. Researchers at Children’s Hospital Los Angeles led by Ching-Ling Lien, PhD... Read More
Published on February 12, 2016
Patients with acute lymphoblastic leukemia are at increased risk for bone fractures due to bone loss resulting from treatment. This decrease in bone density (as illustrated here) can occur as soon as the first month of treatment according to new research out of Children’s... Read More
Published on February 10, 2016
Stickers proclaiming “BPA-free” status are increasingly common on plastic bottles. BPA or Bisphenol A was used at one point to increase the strength of plastic, though was phased out when studies demonstrated the chemical had several significant negative health. Since then, BPS... Read More
Published on February 8, 2016
Leukemia cells (yellow) shown dispersed among fat cells (red) surrounded by supportive cells (blue). Image courtesy of Steven Mittelman, MD, PhD, Children’s Hospital Los Angeles.An interdisciplinary research team at The Saban Research Institute of Children’s Hospital Los Angeles... Read More
Published on February 5, 2016
Throughout football season and leading up to the Super Bowl, an increase in ACL injuries is inevitable. Image courtesy of Shutterstock.A common and often devastating injury in sports – anterior cruciate ligament (ACL) injury can require surgery to restore knee stability and... Read More
Published on February 3, 2016
Neuroblastoma cells under a microscope labeled with fluorescent molecules. Image courtesy of Shutterstock.Building upon more than two decades of basic research conducted at Children’s Hospital Los Angeles, Araz Marachelian, MD, of CHLA, and her colleagues at pediatric academic... Read More
Published on February 2, 2016
Food allergy or intolerance can cause symptoms ranging from a harmless skin rash to a potentially lethal anaphylactic shock. An estimated 15 million Americans suffer from food allergies, many of them children.The prevalence of food allergy is higher among children and is... Read More
Published on January 28, 2016
Exposure to anesthesia during labor and delivery results in morphological changes in the developing fetal brain. Photo credit: Bradley Peterson, MD, Institute of the Developing Mind, Children’s Hospital Los Angeles.Recently recommended in F1000Prime, which identifies significant... Read More
Published on January 26, 2016
A recent study demonstrated a link between bariatric surgery and improved mental health outcome, specifically reduced depression among patients after bariatric surgery. To learn more about the relationship between mental health and obesity in children, we spoke to Mari Radzik,... Read More