Genetic Clotting Disorder in Children

Published on 
October 9, 2015

A blood clot is when blood changes from a liquid to a solid. Blood clots are good because they help your body stop bleeding. But they can form when you don’t need them in veins or arteries. You can have a blood clot in your arteries or veins in places like your arms, legs, eyes, lungs, brain or other organs.

Some kids are born with a genetic condition, which is passed down from a child's parent(s), that makes them at greater risk for a blood clot.

Types of Genetic Clotting Disorders


There are many different types of genetic clotting disorders:

  • Factor V (5) Leiden
  • Prothrombin Mutation
  • Protein C and Protein S Deficiency
  • Antithrombin Deficiency
  • Elevated Homocystein
  • Elevated Lipoprotein (a)
  • Elevated Factor VIII (8)
  • Antiphospholipid Antibody Syndrome (APLA or APLAS)

Symptoms of Blood Clots

The symptoms of a blood clot can be different depending on its location. Symptoms can also depend on if the clot happens in a vein or artery.

Symptoms of a clot in your arm or leg include:

  • Pain in your arm or leg
  • Swelling in your arm or leg
  • Arm or leg may be warm to the touch
  • Not able to move your arm or leg as well
  • Discoloration or purple color of the skin
  • Weak or absent pulse

Symptoms of a clot in your lung include:

  • Chest pain, squeezing or heaviness (some people describe it like an elephant sitting on their chest)
  • Chest pain becomes sharper when taking a breath
  • Shortness of breath or you can’t catch your breath (for no reason)
  • Quick breathing
  • Blueness of extremities Symptoms of a clot in your brain include:
  • Unable to speak normally
  • Hard time moving one side of your body
  • Vision changes
  • Changes in your personality
  • Seizures
  • Headache
  • Part of your face doesn’t look like the other half

Diagnosis and Treatment

  • Genetic clotting disorders are diagnosed using a blood test. To diagnose a blood clot, the following tests can be used:
  • Ultrasound
  • MRI
  • Venogram
  • CT scan

Blood clots are treated using an anticoagulant, a medicine that makes the blood thinner and stops the blood clot from getting bigger. This condition is usually treated for at least 3 months, but the length of treatment depends on where the blood clot is, how it is progressing during treatment and if there are any side effects from the clot.

Visit for more information on how your family can get screened and treated for genetic clotting disorders.