RESEARCH FOCUS
The Biobehavioral Pain Laboratory research is focused on children and adolescents who are evaluated and treated at the Pediatric Pain Management Clinic for chronic pain and other concomitant chronic diseases, such as cancer, obesity and juvenile idiopathic arthritis. We examine and identify neurobiological mechanistic aspects of pain attenuation, the impact of stress and chronic pain on childhood outcomes and interventions that decrease pain and improve overall pediatric/adolescent health outcomes.
Goals
 To understand and examine unconventional medicinal treatments, which are safe and cost-effective to alleviate acute and chronic pain in medically ill children and adolescents.
- To improve infant, child and adolescent health by conducting state-of-the-art pediatric health outcomes research.
Leading-edge Technology Used
- Virtual reality
- Neuroimaging techniques
R ESEARCH TOPICS
Biopsychosocial, neurodevelopmental and neurobehavioral investigations of acute and chronic pain
- Chronic pain and quality of life
- Virtual reality, pain management and neuroimaging
- Chronic illness and posttraumatic stress disorder (PTSD) in medically ill children and adolescents
- Clinical trials investigating pharmacological interventions for chronic pain
Children’s Outcomes, Research and Evaluation (CORE) Program
- Impacting clinical practices and health care policy by demonstrating how medical decisions affect critically ill children and adolescents.
Complementary alternative medicine (CAM)
- Acupuncture treatment
- Biofeedback treatment
- Massage treatment
BIO OVERVIEW
Jeffrey I. Gold, PhD, is an associate professor in the Anesthesiology and Pediatrics departments at the Keck School of Medicine of the University of Southern California (USC). Dr. Gold is a licensed clinical psychologist, a National Institutes of Health-funded clinical researcher and director of the Children’s Outcomes, Research and Evaluation (CORE) program.
He also is director of the Pediatric Pain Management Clinic in the comprehensive multispecialty Pain Management and Palliative Care Program in the Anesthesiology Critical Care Medicine Department at Children’s Hospital Los Angeles and director of the Children’s Hospital Los Angeles – Yo San University Pediatric Acupuncture Program and faculty with specialization in pediatric psychology in the USC University Center of Excellence in Developmental Disabilities Mental Health Services.
SELECTED PUBLICATIONS
1. Vichinsky EP, Neumayr LD, Gold JI, et al. (2010). Neuropsychological Dysfunction and Neuroimaging Abnormalities in Neurologically Intact Adult Patients with Sickle Cell Anemia. Journal of American Medical Association, 303, 1823-1831. PMID: 20460621
2. Horn B, Balk JL, Gold JI (2010). Revisiting the Sham: Is it all Smoke and Mirrors? Evidence-Based Complementary and Alternative Medicine (eCAM), (DOI:10.1093/ecam/neq074) PMID: 21785635
3. Montaño Z, Mahrer NE, Nager A, Claudius I, Gold JI (2010). Assessing Psychosocial Impairment in the Pediatric Emergency Department: Child/Caregiver Concordance. Journal of Child and Family Studies. (DOI:10.1007/s10826-010-9414-3) PMID: 19739456
4. Nager AL, Mahrer NJ, Gold JI (2010). State Trait Anxiety in the Emergency Department: An Analysis of Anticipatory and Life Stressors. Pediatric Emergency Care, 26, 897-901. PMID: 21131802
5. Gold JI, Treadwell MJ, Weissman L, Vichinsky EP (2011). The Mediating Effects of Family Functioning on Psychosocial Outcomes in Healthy Siblings of Children with Sickle Cell Disease. Pediatric Blood & Cancer. PMID: 21360652
6. Li A, Montaño Z, Chen VJ, Gold JI (2011). Virtual Reality and Pain Management: Current Trends and Future Directions. Pain Management, 1, 147-157. PMID: 21779307
7. Nelson LP, Gold JI (2011). Medical Trauma: A review of pediatric trauma and the PICU. Pediatric Critical Care Medicine. PMID: 21798710
8. Christodoulou-Smith J, Gold JI, Mullin PM, Romero R, Goodwin TM, MacGibbon K, Fejzo MS (2011). Posttraumatic Stress Symptoms following Hyperemesis Gravidarum, The Journal of Maternal-Fetal & Neonatal Medicine. PMID: 21635201
9. Gold JI, Nelson LP (2011). Palliative care in a neonatal intensive care unit (NICU). Journal of Critical Care. PMID: 21798710
10. Nager AL , Nager SM, Lalani PL, Gold JI (2011). Holocaust Student Tour: The Impact on Spirituality and Health. Israel Journal of Psychiatry & Related Sciences, 48, 186-194. PMID: 22141143
CURRENT FUNDING
1. National Institutes of Health (NIH)/National Institute on Drug Addiction (NIDA) Cutting-Edge Basic Research Awards (CEBRA)
“Virtual Reality Analgesia: Using fMRI to explore the central mechanisms of VR’s effect on experimentally induced pain in healthy adolescents.”
2. NIH Heart, Lung and Blood Institute (NHBLI) Comprehensive Sickle Cell Centers - NHLBI Clinical Trials Consortium
“Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adult patients with sickle cell disease: a neuropsychological and neuroimaging investigation of adult patients with sickle cell disease”
3. NIH/National Institute of Mental Health (NIMH)
“Validating a child acute stress measure in English and Spanish”
4. NIH/National Institute of Child Health & Human Development (NICHHD)
“Improving Pain and Anxiety in Children Undergoing Surgery”
5. Pfizer Pharmaceutical
“A 15-Week, Randomized, Double Blind, Placebo-Controlled Parallel Group Efficacy Study of Pregabalin in Adolescents (12-16 Years Old) with Fibromyalgia”
“A 6-Month, Open-Label, Safety Trial of Pregabalin in Adolescent Patients with Fibromyalgia”
6. University of Southern California – Children’s Hospital Los Angeles, Southern California – Clinical Translational Science Institute Los Angeles Basin (SC-CTSI LAB)
“Virtual Reality Analgesia: Using fMRI to explore the central mechanisms of VR’s effect on experimentally induced pain in adolescents with fibromyalgia”
7. Green Foundation Grant
Children’s Hospital Los Angeles – Yo San University Pediatric Acupuncture program
8. Forest Laboratories
“A Multicenter, Randomized, Double-Blind, Placebo-Controlled Withdrawal Study to Evaluate the Safety, Tolerability, and Efficacy of Milnacipran in Pediatric Patients with Primary Fibromyalgia”
9. Weingart Foundation Grant
Children’s Hospital Los Angeles – Yo San University Pediatric Acupuncture program
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