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RESEARCH FOCUS

The Biobehavioral Pain Laboratory research is focused on children and adolescents who are evaluated and treated at the Pediatric Pain Management Clinic for chronic pain and other concomitant chronic diseases, such as cancer, obesity and juvenile idiopathic arthritis. We examine and identify neurobiological mechanistic aspects of pain attenuation, the impact of stress and chronic pain on childhood outcomes and interventions that decrease pain and improve overall pediatric/adolescent health outcomes.

Goals

  • To understand and examine unconventional medicinal treatments, which are safe and cost-effective to alleviate acute and chronic pain in medically ill children and adolescents.
  • To improve infant, child and adolescent health by conducting state-of-the-art pediatric health outcomes research.

Leading-edge Technology Used

  • Virtual reality
  • Neuroimaging techniques

RESEARCH TOPICS

Development of a Transdisciplinary USC Center for Integrative Health Research and Education


Biopsychosocial, neurodevelopmental and neurobehavioral investigations of acute and chronic pain

  • Chronic pain and quality of life
  • Virtual reality, pain management and neuroimaging
  • Chronic illness and posttraumatic stress disorder (PTSD) in medically ill children and adolescents
  • Clinical trials investigating pharmacological interventions for chronic pain

Children’s Outcomes, Research and Evaluation (CORE) Program

  • Impacting clinical practices and health care policy by demonstrating how medical decisions affect critically ill children and adolescents.

Complementary alternative medicine (CAM)

  • Acupuncture treatment
  • Biofeedback treatment
  • Massage treatment

BIO OVERVIEW

Jeffrey I. Gold, PhD, is an associate professor in the Anesthesiology and Pediatrics departments at the Keck School of Medicine of the University of Southern California (USC). Dr. Gold is a licensed clinical psychologist, a National Institutes of Health-funded clinical researcher and director of the Children’s Outcomes, Research and Evaluation (CORE) program.

He also is director of the Pediatric Pain Management Clinic in the comprehensive multispecialty Pain Management and Palliative Care Program in the Anesthesiology Critical Care Medicine Department at Children’s Hospital Los Angeles and director of the Children’s Hospital Los Angeles – Yo San University Pediatric Acupuncture Program and faculty with specialization in pediatric psychology in the USC University Center of Excellence in Developmental Disabilities Mental Health Services.

SELECTED PUBLICATIONS

  1. Li A, Montaño Z, Chen VJ, Gold JI (2011) Virtual Reality and Pain Management: Current Trends and Future Directions. Pain Management, 1, 147-157. PMID: 21779307

  2. Nelson LP, Gold JI (2012) Medical Trauma: A review of pediatric trauma and the PICU. Pediatric Critical Care Medicine, 13, 338-347. PMID: 21798710

  3. Mahrer NE, Montaño Z, Gold JI (2012) Relations between Anxiety Sensitivity, Somatization, and Health-Related Quality of Life in Children with Chronic Pain. Journal of Pediatric Psychology, 37, 808-816. PMID: 22493024

  4. Gold JI, Douglas MM, Thomas ML, Elliott JE, Rao S, Miaskowski C (2012) The Relationship Between Posttraumatic Stress Disorder,Mood States, Functional Status, and Quality of Life in Oncology Outpatients. Journal of Pain and Symptom Management. PMID: 22743157

  5. O’Callaghan E, Gold JI (2012) Pica in two children with sickle cell disease: Two case reports. Journal of Pediatric Nursing. PMID: 22917881

  6. Menteer JD, Beas VN, Chang JC, Reed K, Gold JI (2012) Mood and health-related quality of life among pediatric patients with heart failure. Pediatric Cardiology. PMID: 22956059

  7. Yuan HC, Sohn EY, Abou-Ezzeddine T, Mahrer NE, Barber B, Keens TG, Davidson Ward SL, Gold JI (2012) Neurocognitive Functioning in Children with Obstructive Sleep Apnea Syndrome: A pilot study of Positive Airway Pressure Therapy. Journal of Pediatric Nursing, 27, 607-613. PMID: 23101726

  8. Claudius I, Mahrer N, Nager AL, Gold JI (2012) Occult Psychosocial Impairment in a Pediatric Emergency Department Population. Pediatric Emergency Care. PMID: 23187992

  9. Kassam-Adams N, Gold JI, Montaño Z, Kohser KL, Cuadra A, Muñoz C, Armstrong FD (2013)
    Development and psychometric evaluation of child acute stress measures in Spanish and English. Journal of Traumatic Stress, 26, 1-9. PMID: 23371337 

  10. Epstein D, Unger JB, Ornelas B, Chang JC, Markovitz BP, Moromisato DY, Dodek PM, Heylan DK, Gold JI (2013) Psychometric Evaluation of a Modified Version of the Family Satisfaction in the ICU Survey in Parents/Caregivers of Critically Ill Children, Pediatric Critical Care Medicine. PMID: 23863815

  11. Li A, Montaño Z, Chen VJ, Gold JI (2011) Virtual Reality and Pain Management: Current Trends and Future Directions. Pain Management, 1, 147-157. PMID: 21779307

  12. Gold JI, Mahrer NE, Ye J, Palermo TM (2009) Pain, fatigue and health-related quality of life in children and adolescents with chronic pain. Clinical Journal of Pain, 25, 407-412. PMID: 19454874

  13. Gold JI, Kim SH, Kant AJ, Joseph MH, Rizzo A (2006) Effectiveness of virtual reality for pediatric pain distraction during IV placement. CyberPsychology & Behavior, 9, 207-212. PMID: 16640481

  14. Gold JI, Belmont KA, Thomas D (2007) The Neurobiology of Virtual Reality Pain Attenuation. CyberPsychology & Behavior, 10, 536-544. PMID: 17711362


CURRENT FUNDING

1. National Institutes of Health (NIH)/National Institute on Drug Addiction (NIDA) Cutting-Edge Basic Research Awards (CEBRA)
“Virtual Reality Analgesia: Using fMRI to explore the central mechanisms of VR’s effect on experimentally induced pain in healthy adolescents.”

2. NIH Heart, Lung and Blood Institute (NHBLI) Comprehensive Sickle Cell Centers - NHLBI Clinical Trials Consortium
“Neuropsychological dysfunction and neuroimaging abnormalities in neurologically intact adult patients with sickle cell disease: a neuropsychological and neuroimaging investigation of adult patients with sickle cell disease”

3. NIH/National Institute of Mental Health (NIMH)
“Validating a child acute stress measure in English and Spanish”

4. NIH/National Institute of Child Health & Human Development (NICHHD)
“Improving Pain and Anxiety in Children Undergoing Surgery”

5. Pfizer Pharmaceutical
“A 15-Week, Randomized, Double Blind, Placebo-Controlled Parallel Group Efficacy Study of Pregabalin in Adolescents (12-16 Years Old) with Fibromyalgia”

“A 6-Month, Open-Label, Safety Trial of Pregabalin in Adolescent Patients with Fibromyalgia”

6. University of Southern California – Children’s Hospital Los Angeles, Southern California – Clinical Translational Science Institute Los Angeles Basin (SC-CTSI LAB)

“Virtual Reality Analgesia: Using fMRI to explore the central mechanisms of VR’s effect on experimentally induced pain in adolescents with fibromyalgia”

7. Green Foundation Grant
Children’s Hospital Los Angeles – Yo San University Pediatric Acupuncture program

8. Forest Laboratories
“A Multicenter, Randomized, Double-Blind, Placebo-Controlled Withdrawal Study to Evaluate the Safety, Tolerability, and Efficacy of Milnacipran in Pediatric Patients with Primary Fibromyalgia”

9. Weingart Foundation Grant
Children’s Hospital Los Angeles – Yo San University Pediatric Acupuncture program

10. USC Collaboration Fund
Development of a Transdisciplinary USC Center for Integrative Health Research and Education

CONTACT US

Pediatric Biobehavioral Pain Laboratory
4650 Sunset Blvd., MS #12
Los Angeles, CA 90027
Email: Jeffrey I. Gold, PhD
Fax: 323-361-1022

323-361-6341

PRINCIPAL INVESTIGATOR

Jeffrey Gold, PhD

Jeffrey I. Gold, PhD

PubMed Link

Selected Publications

Research Topics

Research Team

Current Funding

Pediatric Pain Management Clinic

Anesthesiology and Critical Care Medicine Research

University Center for Excellence in Developmental Disabilities