A disorder of fibrinolysis is a type of bleeding disorder. Fibrinolysis is the process of dissolving a blood clot after an injury has healed. There are several proteins that are involved in fibrinolysis and the most important protein is called plasminogen. PlasminogenIn order to work, plasminogen needs to be activated by another protein called tissue plasminogen activator (TPA). If there is too much or too little of plasminogen or TPA, fibrinolysis will not work properly. The best known condition that leads to problems in the fibrinolytic system is a lack of plasminogen activator inhibitor. If this protein is missing, the body cannot turn off TPA and if there is too much TPA then blood clots formed normally to stop bleeding get dissolved too early. As a result, bleeding occurs. This condition is very rare and has only been reported in a few families. Treatment
Both medications prevent blood clots from being dissolved by blocking the action of tissue plasminogen activator (TPA). |