Obesity & Diabetes
Research of the Center Endocrinology, Diabetes and Metabolism
The Center for Endocrinology, Diabetes and Metabolism is a major referral center for the Los Angeles area with approximately 13,000 outpatient visits per year and approximately 300 inpatient consultations per year. The Center is well-established and internationally recognized for growth, diabetes, bone, and other endocrine disorders. In 2010, it was recognized by US News & World Report as the top pediatric endocrinology program on the west coast (for the second consecutive year) and the sixth-ranked program in the nation. The division consists of 8 full-time faculty and four part-time faculty, 5 fellows, 9 nurses, 3 dietitians, and 1 social worker, and a part-time psychologist. In addition to clinical care, the Center places a major emphasis on both clinical and basic research, and currently has over $1.5 million in NIH funding. Faculty
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Mitchell Geffner, MD Lily Chao, MD Lynda Fisher, MD Debra Jeandron, MD Francine Kaufman, MD |
Mimi Kim, MD
Steven Mittelman, MD, PhD Roshanak Monzavi, MD Pisit Pitukcheewanont, MD |
Scholarly Publications
Backeljauw P, Bang P, Clayton PE, Geffner ME, Woods KA. Diagnosis and management of primary insulin-like growth factor-I deficiency: current perspectives and clinical update. Pediatr Endocrinol Rev. 2010 Feb;7(Suppl 1):154-71. PMID: 20463651.
Behan JW, Avramis VI, Yun JP, Louie SG, Mittelman SD. Diet-induced obesity alters vincristine pharmacokinetics in blood and tissues of mice. Pharmacol Res. 2010 May;61(5):385-90. Epub 2010 Jan 18. PMID: 20083201; PMCID: PMC2848885.
Behan JW, Yun JP, Proekter MP, Ehsanipour EA, Arutyunyan A, Moses AS, Louie S, Avramis VI, Butturini A, Heisterkamp N, Mittelman SD. Adipocytes impair leukemia treatment in mice. Cancer Res. 2009 Oct 1;69(19):7867-74. PMID: 19773440; PMCID: PMC2756308.
Chao LC, Wroblewski K, Zhang Z, Pei L, Vergnes L, Ilkayeva OR, Ding SY, Reue K, Watt MJ, Newgard CB, Pilch PF, Hevener AL, Tontonoz P. Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. Diabetes. 2009 Dec;58(12):2788-96. Epub 2009 Sep 9. PMID: 19741162; PMCID: PMC2780886.
Chen W, Kim MS, Shanbhag S, Arai A, VanRyzin C, McDonnell NB, Merke DP. The phenotypic spectrum of contiguous deletion of CYP21A2 and tenascin XB: quadricuspid aortic valve and other midline defects. Am J Med Genet. 2009 Dec;149A(12):2803-8. PMID: 19921645; PMCID: PMC2963110.
Cohen P, Germak J, Rogol AD, Weng W, Kappelgaard AM, Rosenfeld RG; American Norditropin Study Group. Variable degree of growth hormone (GH) and insulin-like growth factor (IGF) sensitivity in children with idiopathic short stature compared with GH-deficient patients: evidence from an IGF-based dosing study of short children. J Clin Endocrinol Metab. 2010 May;95(5):2089-98. PMID: 20207829.
DeBar LL, Schneider M, Ford EG, Hernandez AE, Showell B, Drews KL, Moe EL, Gillis B, Jessup AN, Stadler DD, White M; HEALTHY Study Group. Social marketing-based communications to integrate and support the HEALTHY study intervention. Int J Obes (Lond). 2009 Aug;33(Suppl 4):S52-9. PMID: 19623190; PMCID: PMC2747750.
Drews KL, Harrell JS, Thompson D, Mazzuto SL, Ford EG, Carter M, Ford DA, Yin Z, Jessup AN, Roullet JB; HEALTHY Study Group. Recruitment and retention strategies and methods in the HEALTHY study. Int J Obes (Lond). 2009 Aug;33(Suppl 4):S21-8. PMID: 19623184; PMCID: PMC2758033.
Franklin SL, Austin J, Reh CS, Ma NS, Kim M. 2009 annual meeting of the Endocrine Society Washington DC, United States (June 10-13, 2009)--selected highlights. Pediatr Endocrinol Rev. 2009 Dec;7(2):130-8. PMID: 20183933.
Franklin SL, Geffner ME. Growth hormone: the expansion of available products and indications. Endocrinol Metab Clin North Am. 2009 Sept;38(3):587-611. PMID: 19717006.
Gillis B, Mobley C, Stadler DD, Hartstein J, Virus A, Volpe SL, El ghormli L, Staten MA, Bridgman J, McCormick S; HEALTHY Study Group. Rationale, design and methods of the HEALTHY study nutrition intervention component. Int J Obes (Lond). 2009 Aug;33(Suppl 4):S29-36. PMID: 19623185; PMCID: PMC2754734.
Geffner ME. Aromatase inhibitors to augment height: continued caution and study required. J Clin Res Pediatr Endocrinol. 2009;1(6):256-261. DOI: 10.4274/jcrpe.v1i6.256
Geffner ME. GH treatment: the transition period between adolescence and adulthood. J Clin Res Pediatr Endocrinol. 2009;1:205-298.
Gilsanz V, Chalfant J, Mo AO, Lee DC, Dorey FJ, Mittelman SD. Reciprocal relations of subcutaneous and visceral fat to bone structure and strength. J Clin Endocrinol Metab. 2009 Sept;94(9):3387-93. Epub 2009 Jun 16. PMID: 19531595; PMCID: PMC2741723.
Hirst K, Baranowski T, DeBar L, Foster GD, Kaufman F, Kennel P, Linder B, Schneider M, Venditti EM, Yin Z; HEALTHY Study Group. Healthy study rationale, design and methods: moderating risk of type 2 diabetes in multi-ethnic middle school students. Int J Obes (Lond). 2009 Aug;33(Suppl 4):S4-20. PMID: 19623188; PMCID: PMC2782907.
Hoey H; Hvidoere Study Group on Childhood Diabetes. Psychosocial factors are associated with metabolic control in adolescents: research from the Hvidoere Study Group on Childhood Diabetes. Pediatr Diabetes. 2009 Dec;10(Suppl 13):9-14. PMID: 19930221.
Ma NS, Malloy PJ, Pitukcheewanont P, Dreimane D, Geffner ME, Feldman D. Hereditary vitamin D resistant rickets: identification of a novel splice site mutation in the vitamin D receptor gene and successful treatment with oral calcium therapy. Bone. 2009 Oct;45(4):743-6. PMID: 19523546; PMCID: PMC2782671.
Kaufman FR. Diabetes study findings: what do they mean? School Nurse News. 2009 Sep;26(4):10-1. PMID: 19791478.
Kaufman FR. Hyperglycemia management in students with diabetes. NASN Sch Nurse. 2009 May;24(3):108-10. PMID: 20437673.
Kim MS, Merke DP. Cardiovascular disease risk in adult women with congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Semin Repro Med. 2009 Jul;27(4):316-21. Epub 2009 Jun 15. PMID: 19530065.
Koltowska-Häggström M, Geffner ME, Jönsson P. Monson JP, Abs R, Hána V, Höybye C, Wollmann HA. Discontinuation of growth hormone (GH) treatment during the transition phase is an important factor determining the phenotype of young adults with nonidiopathic childhood-onset GH deficiency. J Clin Endocrinol Metab. 2010 Jun;95(6):2646-54. PMID: 20335451.
Ma NS, Fink C, Geffner ME, Borchert MD. Evolving central hypothyroidism in children with optic nerve hypoplasia. J Pediatr Endocrinol Metab. 2010 Jan-Feb;23(1-2):53-8. PMID: 20432806.
Ma NS, Shah AJ, Geffner ME, Kapoor N. Igf-I stimulates in vivo thymopoiesis after stem cell transplantation in a child with Omenn syndrome. J Clin Immunol. 2010 Jan;30(1):114-20. Epub 2009 Sep 24. PMID: 19777327.
McMurray RG, Bassin S, Jago R, Bruecker S, Moe EL, Murray T, Mazzuto SL, Volpe SL; HEALTHY Study Group. Rationale, design and methods of the HEALTHY study physical education intervention component. Int J Obes (Lond). 2009 Aug;33(Suppl 4):S37-43. PMID: 19623187; PMCID: PMC2747738.
Mittelman SD, Gilsanz P, Mo AO, Wood J, Dorey F, Gilsanz V. Adiposity predicts carotid intima-media thickness in healthy children and adolescents. J Pediatr. 2010 Apr;156(4):592-7.e2. Epub 2009 Dec 14. PMID: 20004913.
Mittelman SD, Klier K, Braun S, Azen C, Geffner ME, Buchanan TA. Obese adolescents show impaired meal responses of the appetite-regulating hormones ghrelin and PYY. Obesity (Silver Spring). 2010 May;18(5):918-25. PMID: 20094039; PMCID: PMC2940837.
Pitukcheewanont P, Punyasavatsut N, Feuille M. Physical activity and bone health in children and adolescents. Pediatr Endocrinol Rev. 2010 Mar-Apr;7(3):275-82. PMID: 20526241.
Reh CS, Geffner ME. Somatotropin in the treatment of growth hormone deficiency and Turner syndrome in pediatric patients: a review. Clin Pharmacol Adv Appl. 2010 Jun;2010(2):111-122. DOI: 10.2147/CPAA.S6525.
Schneider M, Hall WJ, Hernandez AE, Hindes K, Montez G, Pham T, Rosen L, Sleigh A, Thompson D, Volpe SL, Zeveloff A, Steckler A; HEALTHY Study Group. Rationale, design and methods for process evaluation in the HEALTHY study. Int J Obes (Lond). 2009 Aug;33(Suppl 4):S60-7. PMID: 19623191; PMCID: PMC2749285.
TODAY Study Group. Design of a family-based lifestyle intervention for youth with type 2 diabetes: the TODAY study. Int J Obes (Lond). 2010 Feb;34(2):217-26. PMID: 19823189; PMCID: PMC2822093.
Verma S, Vanryzin C, Sinaii N, Kim MS, Nieman LK, Ravindran S, Calis KA, Arlt W, Ross RJ, Merke DP. A pharmacokinetic and pharmacodynamic study of delayed- and extended-release hydrocortisone (Chronocort™) vs. conventional hydrocortisone (Cortef™) in the treatment of congenital adrenal hyperplasia. Clin Endocrinol (Oxf). 2010 Apr;72(4):441-7. Epub 2009 May 25. PMID: 19486026; PMCID: PMC2866132.
Venditti EM, Elliot DL, Faith MS, Firrell LS, Giles CM, Goldberg L, Marcus MD, Schneider M, Solomon S, Thompson D, Yin Z; HEALTHY Study Group. Rationale, design and methods of the HEALTHY study behavior intervention component. Int J Obes (Lond). 2009 Aug;33(Suppl 4):S44-51. PMID: 19623189; PMCID: PMC2747742.
Wood J, Rami B. Report of the 35th ISPAD-Meeting, Ljubljana, Slovenia, 2-5 September 2009. Pediatr Diabetes. 2010 Feb;11(1):74-80. Epub 2009 Dec 2. PMID: 19958459.