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ChiLDREN Liver Research Center

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We are one of 14 children’s hospitals across the nation that is a designated site of the National Institutes of Health (NIH) funded Childhood Liver Disease Research and Education Network (ChiLDREN).

ChiLDREN represents the continuation of two previous NIH-funded consortia, the Biliary Atresia Research Consortium (BARC) and the Cholestatic Liver Consortium (CLiC).

Center Goals

The goals of ChiLDREN are:

  1. To study rare pediatric liver diseases such as biliary atresia, alpha-1-antitrypsin deficiency, progressive familial intrahepatic cholestasis, Alagille syndrome, bile acid synthesis defects, and mitochondrial hepatopathies.
  2. To provide a resource for education on these rare liver conditions for families, pediatricians, and gastroenterologists.

Save the Date for Biliary Artresia Day on Saturday, October 15, 2011Save the Date for
Biliary Artresia Day
Saturday, October 15

Current Studies

We are currently enrolling infants and children into:

  • A Prospective Database of Infants with Cholestasis (PROBE): This study is open to infants less than 180 days of age diagnosed with cholestasis (blockage of bile flow).
  • A Randomized, Double-Blinded, Placebo-Controlled Trial of Corticosteroid Therapy Following Portoenterosotomy in Infants With Biliary Atresia (START): This study is open to infants less than 180 days of age diagnosed with biliary atresia who are also enrolled in a Prospective Database of Infants with Cholestasis (PROBE).
  • Biliary Atresia Study in Infants and Children (BASIC): This study is open to infants and children over 1 year of age diagnosed with biliary atresia.
  • Longitudinal Study of Genetic Casues of Intrahepatic Cholestasis (LOGIC): This study is open to children, adolescents, and young adults diagnosed with one of four types of cholestasis (blockage of bile flow): Alagille syndrome, alpha-1 antitrypsin deficiency, progressive familial intrahepatic cholestasis, and bile acid synthesis defects.
  • Longitudinal Study of Mitochondrial Hepatopathies (MITOHEP). This study is open to infants and children with diagnosed or suspected mitochondrial hepatopathy.

Our Team

Our ChiLDREN Liver Center is headed by Kasper S. Wang, MD, FACS, FAAP (a pediatric surgeon) Sonia Michail, MD, Danny Thomas, MD (pediatric gastroenterologists) and Research Coordinator, Cat Goodhue, CPNP.

Principal Investigator

Kasper S. Wang, MD

Co-Investigator

Sonia Michail, MD

Dr. Michail Sonia

Co-Investigator

Danny Thomas, MD

 

Research Coordinator

Cat Goodhue CPNP

Dr. Wang is a board certified pediatric surgeon
with a special interest in pediatric liver diseases.

Dr. Michail is a board certified pediatric gastroenterologist whose primary specialty is pediatric gastroenterology.

Dr. Thomas is the Division Head, Gastroenterology and Nutrition and Professor of Clinical Pediatrics, Keck/USC School of Medicine.

Ms. Goodhue is a bard certified pediatric nrse practitioner with experience in conducting clinical trials.

Our participation in ChiLDREN represents a multidisciplinary effort utilizing the expertise of:

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