ChiLDREN Liver Research Center
Information
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We are one of 14 children’s hospitals across the nation that is a designated site of the National Institutes of Health (NIH) funded Childhood Liver Disease Research and Education Network (ChiLDREN).
ChiLDREN represents the continuation of two previous NIH-funded consortia, the Biliary Atresia Research Consortium (BARC) and the Cholestatic Liver Consortium (CLiC).
Center Goals
The goals of ChiLDREN are:
- To study rare pediatric liver diseases such as biliary atresia, alpha-1-antitrypsin deficiency, progressive familial intrahepatic cholestasis, Alagille syndrome, bile acid synthesis defects, and mitochondrial hepatopathies.
- To provide a resource for education on these rare liver conditions for families, pediatricians, and gastroenterologists.
Current Studies
We are currently enrolling infants and children into:
- A Prospective Database of Infants with Cholestasis (PROBE): This study is open to infants less than 180 days of age diagnosed with cholestasis (blockage of bile flow).
- A Randomized, Double-Blinded, Placebo-Controlled Trial of Corticosteroid Therapy Following Portoenterosotomy in Infants With Biliary Atresia (START): This study is open to infants less than 180 days of age diagnosed with biliary atresia who are also enrolled in a Prospective Database of Infants with Cholestasis (PROBE).
- Biliary Atresia Study in Infants and Children (BASIC): This study is open to infants and children over 1 year of age diagnosed with biliary atresia.
- Longitudinal Study of Genetic Casues of Intrahepatic Cholestasis (LOGIC): This study is open to children, adolescents, and young adults diagnosed with one of four types of cholestasis (blockage of bile flow): Alagille syndrome, alpha-1 antitrypsin deficiency, progressive familial intrahepatic cholestasis, and bile acid synthesis defects.
- Longitudinal Study of Mitochondrial Hepatopathies (MITOHEP). This study is open to infants and children with diagnosed or suspected mitochondrial hepatopathy.
Our Team
Our ChiLDREN Liver Center is headed by Kasper S. Wang, MD, FACS, FAAP, a pediatric surgeon, Sylvie Lebel, MD, a pediatric hepatologist, and Research Coordinator, Cat Goodhue, CPNP.
Principal Investigator
Kasper S. Wang, MD
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Co-Investigator
Sylvie Lebel, MD
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Research Coordinator
Cat Goodhue CPNP
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Dr. Wang is a Board Certified
Pediatric Surgeon
with a special interest in pediatric liver diseases. |
Dr. Lebel is a Board Certified Pediatric Hepatologist. |
Ms. Goodhue is a Board Certified Pediatric Nurse Practitioner with experience in conducting clinical trials. |
Our participation in ChiLDREN represents a multidisciplinary effort utilizing the expertise of:
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