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Timothy J. Triche, M.D., Ph. D., will Develop the New Center for Personalized Medicine at Childrens Hospital Los Angeles

The Center for Personalized Medicine will coordinate, support and expand basic and translational research in genomics, proteomics, bioinformatics, molecular genetics, molecular microbiology and cytogenetics

CONTACT: Steve Rutledge at (323) 361-4121

LOS ANGELES – Timothy J. Triche, M.D., Ph.D., who has been chair of the Department of Pathology & Laboratory Medicine and pathologist-in-chief at Childrens Hospital Los Angeles, and vice chairman of the Department of Pathology and professor of pathology and pediatrics at the Keck School of Medicine since 1988, will focus “…his significant background and experience, and his considerable intellectual capital,” on the development of the new Center for Personalized Medicine (CPM), which will coordinate, support and expand the hospital’s basic and translational research in genomics, proteomics, bioinformatics, molecular genetics, molecular microbiology and cytogenetics, according to Childrens Hospital Los Angeles President and CEO Richard D. Cordova, FACHE. 

“This is the future,” Mr. Cordova said, adding that we are “…fortunate to have a person of Dr. Triche’s background and experience to develop and lead this new initiative at Childrens Hospital Los Angeles.”  He said that it is his expectation that Dr. Triche will become the first director of the Center for Personalized Medicine.

He said that the CPM at Childrens hospital Los Angeles will coordinate and support “…our work in genomics, proteomics and bioinformatics, especially as applied to the diagnosis, management and treatment of diseases in children,” adding that it is “…an absolutely vital component of our commitment to the research enterprise, consistent with our [Vision 2020] research planning and the vital work of The Saban Research Institute.”

Dr. Triche will also spend his time and talent on his own substantial research program and the clinical services provided by the Molecular Pathology and Genomics Laboratory.  At present, his annual research funding is in excess of $3 million per year and supports six graduate students, two post-doctoral fellows, junior faculty, two core facilities, and multiple national and international collaborations.

Dr. Triche has agreed to remain as chair of the Department of Pathology & Laboratory Medicine and pathologist-in-chief while we conduct a national search for his successor; the search committee, which will be chaired by Dr. Stuart E. Siegel, who is head of the Division of Hematology/Oncology and director of the Childrens Center for Cancer and Blood Diseases at Childrens Hospital Los Angeles, and professor and vice chairman of pediatrics at the Keck School of Medicine.

Dr. Triche was director of Specialized Diagnostics, Pathology, at the National Institutes of Health and section chief in the Laboratory of Pathology at the National Cancer Institute of the National Institutes of Health, from 1975 to 1988.

He also has been a member of the Childrens Hospital Los Angeles Board of Trustees (1989-95) and the Research Institute (1995-2000), which is now The Saban Research Institute of Childrens Hospital Los Angeles.

Dr. Triche is board certified in anatomic pathology.

His major areas of research interest include biology and molecular genetics of childhood and adult cancer; correlation of sarcoma gene expression profiles and clinical outcomes; identification and validation of diagnostic, prognostic and therapeutic gene targets; mechanisms of action of chimeric genes in childhood sarcomas; the development of systemic targeted small molecule and siRNA cancer therapy; and pathogenesis of age-related macular degeneration. Most recently, the National Cancer Institute of the National Institutes of Health, the USC Norris Comprehensive Cancer Center, the Beckman Foundation, the USC Provost’s Genomic Initiative, the Whittier Foundation, the Institute for Pediatric Clinical Research, the Department of Defense, the Department of Energy, and the Children’s Oncology Group are funding his research.

Dr. Triche is the author of 188 peer-reviewed publications, 176 abstracts and 39 book chapters.

He is a frequent speaker throughout the United States and around the world.

He received an Outstanding Service Award from the United States Public Health Service (USPHS) for his work on childhood cancer and has been named as one of the ‘Best Doctors in America’ since 2004, among other awards and invited professorships.

Dr. Triche has served on numerous national committees of the Children’s Oncology Group (COG), where he is presently a member of the executive committee (2001-present), the scientific council (2001-present) and associate chair for research (2001-present).  Previously he was a member of the Children’s Cancer Group (CCG), where he was Pathology Discipline Chair. He was also a member of the Intergroup Rhabdomyosarcoma Study Group (RSG). He was a founding member of the Association of Molecular Pathology.

Dr. Triche serves on several subcommittees of the National Cancer Institute, including those for basic, pre-clinical, and clinical cancer studies (Subcommittees C, D and E). He was also a founding member of Cancer Biomarkers Study Section until his appointment to these subcommittees.

Dr. Triche is a member of the International Society of Bone and Soft Tissue Pathology (2001-present), the Connective Tissue Oncology Society (2001-present), the College of American Pathologists (1991-present), the Association for Molecular Pathology (1995-present), the American Association for Cancer Research (1988-present), the American Society of Clinical Pathologists (1988-present), the American Society of Investigative Pathology (1995-present), the Society for Pediatric Pathology (1995-present),  the U.S. and Canadian Academy of Pathology (1990-present), the International Academy of Pathology (1974-present) and the American Association for the Advancement of Science (1988-present).

Dr. Triche received a bachelor’s degree from Cornell University in 1966. He received a medical degree and a Ph.D from the Tulane University School of Medicine in 1971. He completed an internship (1971-72) and residencies in pathology (1972-73) and in surgical pathology (1973-74) at Washington University Medical School/Barnes Hospital in St. Louis.

Dr. Triche was Senior Staff Fellow in the Laboratory of Pathology at the National Cancer Institute of the National Institutes of Health, Bethesda, Maryland, in 1974-75, when he was offered the tenured position at the NCI he held until he came to Childrens Hospital Los Angeles in 1988.
Founded in 1901, Childrens Hospital Los Angeles has been treating the most seriously ill and injured children in Los Angeles for more than a century, and it is acknowledged throughout the United States and around the world for its leadership in pediatric and adolescent health. Childrens Hospital is one of America’s premier teaching hospitals, affiliated with the Keck School of Medicine of the University of Southern California since 1932. It is a national leader in pediatric research. 

Since 1990, U.S. News & World Report and its panel of board-certified pediatricians have named Childrens Hospital Los Angeles one of the top pediatric facilities in the nation, and it is ranked among the Top 10 children’s hospitals in the country – and first among the 13 children’s hospitals in California – in the current magazine rankings.