Assistant Professor, Pediatrics Neuroscience Program
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Publications: 

Makita, T., Sucov, H.M., Gariepy, C.E., Yanagisawa, M., and Ginty, D.D. (2007). Endothelins are vascular-derived axonal guidance cues for developing sympathetic neurons. Nature 452: 759-63, 2008.

Choudhary, B., Ito, Y., Makita, T., Sasaki, T., Chai, Y., and Sucov, H.M. (2006). Cardiovascular malformations with normal smooth muscle differentiation in neural crest-specific type II TGFbeta receptor (Tgfbr2) mutant mice. Dev. Biol., 289:420-9

Makita, T, Duncan, S.A., and Sucov, H.M. (2005). Retinoic acid, hypoxia and GATA factors cooperatively control the onset of fetal liver erythropoietic differentiation. Dev. Biol., 280:59-72.

Chen, T.H., Chang, T.C., Kang, J.O., Choudhary, B., Makita, T., Tran, C.M., Burch, J.B., Eid, H., and Sucov, H.M. (2002). Epicardial induction of fetal cardiomyocyte proliferation via a retinoic acid-inducible trophic factor. Dev. Biol., 250:198-207.

Huang, J., Powell, W.C., Khodavirdi, A.C., Wu, J., Makita, T., Cardiff, R.D., Cohen, M.B., Sucov, H.M., and Roy-Burman, P. (2002). Prostatic intraepithelial neoplasia in mice with conditional disruption of the retinoid X receptor alpha allele in the prostate epithelium. Cancer Res., 62:4812-9.

Research Interests: 

A key process in developmental neurobiology is the manner by which axons projecting from newly born neurons choose routes to reach and ultimately innervate distant target organs. This process is called axon guidance and is characterized by the importance of instructional cues that direct axonal outgrowth. Only a limited number of guidance molecules are currently known, far less than sufficient to explain the complexity of the nervous system.

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