Chief of the Division of Urology; Co-Director, GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology; Associate Professor of Pediatric Urology, Keck School of Medicine, USC; Co-surgical director, CAH Comprehensive Care Clinic
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Dr. De Filippo was named chief of the Division of Urology in 2014, having served interim chief since 2012, overseeing and maintaining the Division’s robust clinical and research programs. Among the many advances made during his tenure, Urology became one of the first surgical divisions at Children’s Hospital Los Angeles to implement electronic medical record-keeping in the outpatient clinic as well as in its extensive satellite network, which includes 15 offices across the Southern California region.

Currently Dr. De Filippo is researching: The development of working renal units from stem cell sources in the laboratory for eventual transplantation in animal recipients as a viable donor kidney source, the use of amniotic fluid stem cells for cell therapeutic modes of therapy in acute and chronic renal failure, FDA-approved phase II clinical trial for tissue engineering of the bladder, isolation of progenitor cells for tissue engineering and cell therapy from amniotic fluid, multipotent stem cells and progenitor cells from amniotic fluid for the treatment of alport disease, the use of multipotent stem cells from amniotic fluid for fetal therapy for alport disease as a model for fetal therapies in genetic diseases of the kidney, the use of multipotent and progenitor stem cells from amniotic fluid for diabetes and diabetic nephropathy.

Clinical Interests

Fetal Urology, Complex Genitourinary Reconstruction (Bladder Exstrophy, Ambiguous Genitalia and Congenital Adrenal Hyperplasia), Clinical trials for Tissue Engineered Transplantation of Neo-organs, Robotic Surgery.

Education

Medical School: 

Keck School of Medicine, University of Southern California

Internship: 

Keck School of Medicine, University of Southern California, LAC-USC Medical Center and Affiliate Hospitals, Surgery

Residency: 

Keck School of Medicine, University of Southern California, LAC-USC Medical Center and Affiliate Hospitals, Urology

Fellowship: 

Research Fellowship in Tissue Engineering/ Children's Hospital Boston, Harvard Medical School. Pediatric Urology/Children's Hospital Boston, Harvard Medical School.

Accomplishments

Certification: 

Diplomate of the American Board of Urology, and Pediatric Urology (Subspecialty Certification, American Board of Urology)

Medical Memberships: 

American Academy of Pediatrics Section on Urology; American Urological Association; American Urological Association; Western Section, Tissue Engineering Society International

Medical Awards: 

Top Doctors, Pasadena Magazine 2009 Best Doctors in the San Gabriel Valley 2008 America's Top Urologists 2008 Wright Foundation Award 2007 Laboratory awarded California Institute for Regenerative Medicine PostDoctoral Fellowship 2006 American Foundation of Urological Disease Research Scientist Award 2005 Baxter Research Award 2005 Poster Prize CHLA Research Day 2004 Von. L. Meyer Traveling Fellowship Award,2000 1st prize recipient for basic science research in tissue engineering, Clinical and Basic science research day Children's Hospital, Boston, MA,2000 American Foundation Of Urologic Disease (AFUD) Scholarship recipient,2000 Winner of AUA/Pfizer Visiting Professorship Essay,1998 Outstanding House Officer Teaching Award,1998 Resident Teacher of the Year Award,1995 Graduated Dean's Scholar for Academic Excellence from University of Southern California School of Medicine,1993

Other Information

Specialty Interest: 

Advanced Fetal Care, Organ Regeneration, Stem Cell Research, Tissue Engineering

Publications: 

 Autologous cell seeded biodegradable scaffold for augmentation cystoplasty: phase II study in children and adolescents with spina bifida. Joseph DB, Borer JG, De Filippo RE, Hodges SJ, McLorie GA. Journal of Urology. 2014 May;191(5):1389-95. doi: 10.1016/j.juro.2013.10.103. Epub 2013 Oct 29.

Amniotic fluid stem cells prevent β-cell injury. Villani V, Milanesi A, Sedrakyan S, Da Sacco S, Angelow S, Conconi MT, Di Liddo R, De Filippo R, Perin L. Cytotherapy. 2014 Jan;16(1):41-55. doi: 10.1016/j.jcyt.2013.08.010. Epub 2013 Nov 7.

A novel source of cultured podocytes. Da Sacco S, Lemley KV, Sedrakyan S, Zanusso I, Petrosyan A, Peti-Peterdi J, Burford J, De Filippo RE, Perin L.
PLoS One. 2013 Dec 12;8(12):e81812. doi: 10.1371/journal.pone.0081812. eCollection 2013.

A novel mutation of anti-Mullerian hormone gene in Persistent Mullerian Duct Syndrome presented with bilateral cryptorchidism: a case report. Wongprasert H, Somanunt S, De Filippo R, Picard JY, Pitukcheewanont P. Journal of Pediatric Urology. 2013 Aug;9(4):e147-9. doi: 10.1016/j.jpurol.2013.03.004. Epub 2013 Apr 20.

Anorectal malformation and associated end-stage renal disease: management from newborn to adult life. Giuliani S, Midrio P, De Filippo RE, Vidal E, Castagnetti M, Zanon GF, Gamba PG. Journal of Pediatric Surgery. 2013 Mar;48(3):635-41. doi: 10.1016/j.jpedsurg.2012.10.073. Review.

Research Interests: 

DEFILIPPO_LAB_BANNER.JPG

Research Topics 

  • Regenerative medicine and tissue engineering research using stem cells for neo-organ regeneration and cell therapeutics

  • Kidney replacement and novel stem cell treatments for various causes of renal failure 

  • Laboratory for organ regenerative research and cell therapeutics in Urology

Research Overview

Roger De Filippo, MD and Laura Perin, PhD, principal investigators and co-directors of the GOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, focus on the development of new stem cell therapeutics and other techniques for organ regeneration.

Using a model for Alport’s Syndrome, a kidney disease characterized by progressive renal fibrosis, the research team injected Amniotic Fluid Stem Cells (AFSC) early in the course of the disease and found that the treatment increased survival time and ameliorated the decline in kidney function.

Kidneys are responsible for filtering toxins from the blood. Chronic kidney disease (CKD) affects millions of children and adults in the United States.  Characterized by a progressive decline in kidney function, CKD leads to an increase in health problems, including heart disease and diabetes. Those who develop end-stage kidney disease depend on dialysis to clear the waste from their blood and, ultimately, most patients require a kidney transplant in order to survive. With such stark long-term consequences, this novel research offers hope to those suffering from the disease and is also a significant advancement in the stem cell research field.

Stem cell therapies have emerged over the last twenty years as a promising new area of biomedical research. While embryonic stem cells remain a controversial subject, AFSC are found in the fluid surrounding a fetus. The cells can be collected via amniocentesis or at birth without any harmful effects. The lab’s research demonstrates that the therapeutic benefit of AFSC is similar to that of embryonic stem cells.

Current projects include kidney organ repair techniques with stem cells, as well as, new stem cell therapy studies for lung, heart, diabetes and kidney diseases. The goal is to search for potential applications that could be used to prevent these diseases and significantly delay the damage they cause.

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